Actinic keratosis (AK) is a precursor to cutaneous squamous cell carcinoma (SCC). Effective therapeutics eliminate AKs and prevent SCC are lacking. Long treatment durations severe side effects have limited the efficacy of cytotoxic AK treatments including 5-fluorouracil (5-FU) chemotherapy photodynamic therapy. Previously, we shown that thymic stromal lymphopoietin (TSLP), an epithelium-derived...

Actinic Keratoses (AKs) are premalignant intraepithelial skin lesions that can progress to cutaneous squamous cell carcinoma (SCC). The field of cancer immunotherapy has demonstrated the ability immune system treat late-stage cancers. We have shown also be leveraged prevent through a randomized, double-blind clinical trial. Topical calcipotriol plus 5-fluorouracil (5-FU) effectively eliminates ...

cancer immunotherapy (passive or active) involves treatments which promote the ability of the immune system to fight tumor cells. several types of immunotherapeutic agents, such as monoclonal antibodies, immune checkpoint inhibitors, non-specific immunomodulatory agents, and cancer vaccines are currently under intensive investigation in preclinical and clinical trials. cancer vaccines induce pe...

the b-cell cd20 antigen is one of the most reliable surface targets in immunotherapy of b lymphoma. in this project, we studied the production and characterization of a new monoclonal antibody against chimeric human cd20 extra loops (hcd20 exl). the results showed that clone c12h, igg2/k isotype reacted with the antigen in elisa and immunoblot. the kd value was  found to be 2×10-9m and flow cyt...

introduction: epidermal growth factor receptor (egfr) has been shown to play a critical role in tumor cell growth and its overexpression has been observed in many epithelial tumors. in the field of cancer vaccine research, displaying the peptide mimotope on the surface of phage particles has shown promising results. methods: in this study using m13-pviii phage display system, two constructs wer...

Background: Narrow band Ultraviolet B (NBUVB) has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been used as immunotherapy or as a part of combination therapies. The aim of this study was to compare the clinical efficacy and safety of NBUVB and NBUVB plus topical calcipotriol in the treatment of generalized vitiligo. Methods: NBUVB phototherapy wa...