Learning latent representations is playing a pivotal role in machine learning and many application areas. Previous work on the relational topic model (RTM) has shown promise on learning latent topical representations for describing relational document networks and predicting pairwise links. However under a probabilistic formulation with normalization constraints, RTM could be ineffective in con...

The present work was performed with the objective of novel topical formulation development poorly water-soluble drug Diclofenac diethylamine by loading drug-containing nanosponge into formulation. nanosponges are polymeric nanoparticles that entrap drug. drug-loaded has different absorption characteristics in comparison to pure delivery system. Methods: first loaded ethylcellulose using emulsio...

Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol® hyd...

BACKGROUND Postoperative erythema of several months duration is a universal and problematic side effect of cutaneous carbon dioxide (CO2) laser resurfacing. OBJECTIVE This study was conducted in order to determine the effectiveness of two formulations of topical ascorbic acid in reducing the degree and duration of post-CO2 laser resurfacing erythema. RESULTS The application of topical L-asc...

Purpose: Current available topical formulations containing non-steroidal anti-inflammatory drugs (NSAIDs) suffer from inadequate efficacy due to drug limited solubility (class II of Biopharmaceutics Classification System) responsible for the incomplete absorption of the administered dose in the application site. Another problem is represented by inadequate formulation, difficult to be applied b...

PURPOSE The aim of the present study was the in vitro and in vivo evaluation of a novel aqueous formulation based on polymeric micelles for the topical delivery of cyclosporine A for dry eye treatment. METHODS In vitro experiments were carried out on primary rabbit corneal cells, which were characterized by immunocytochemistry using fluorescein-labeled lectin I/isolectin B4 for the endothelia...

BACKGROUND Boswellic acids (BAs) show anti-inflammatory properties in a variety of inflammatory diseases, including rheumatoid arthritis, osteoarthritis, and asthma. A topical administration route is currently used to deliver active compounds in psoriatic and eczematous patients. In this double-blind study we compare a novel BA formulation (containing Bosexil(®), INCI [International Nomenclatur...

Topical analgesics are in need to be differentiated from transdermal formulations of analgesics. Topical analgesics are characterized by local analgesic effects in the absence of systemic effects, and do not require a transdermal delivery formulation. There are two key issues in the development of topical analgesics. 1. For optimal clinical effects specific characteristics for the vehicle (a cr...

Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol® hyd...