Fixed-dose combination topical therapy with corticosteroid and vitamin D analog provides effective treatment and possible long-term management of psoriasis. The anti-inflammatory and immunomodulatory effects of corticosteroids and vitamin D analogs in treating psoriasis are well investigated; their complementary effects lead to the disruption of the inflammatory feedback loop underlying psorias...

BACKGROUND Psoriasis vulgaris (PV) has been causing increasing concern due to its highly prevalent, harmful and therapy-resistant characteristics. The YXBCM01 (Chinese herbal medicine) for PV trial evaluates the effects of YXBCM01 on relapse rate in patients suffering from PV. As an update to the published design and method for the trial, this paper presents the statistical plan for the main pu...

BACKGROUND Probably related to immune dysfunction, psoriasis vulgaris is a chronic, painful, disfiguring and disabling dermatological disease, carrying an increased risk of serious comorbidities. Current conventional therapies can be costly, show risks of side effects and have limited efficacy, with relapse common on treatment cessation. Chinese herbal medicine is effective in treating psoriasi...

Charged sodium channel blockers (CSCBs) such as NTX-2009 do not cross membranes, and selectively inhibit sensory nerves by gaining access to nociceptors through large pore channels (eg TRPV1, TRPA1) that are open due inflammation. Evidence suggests transmit itch pain signals the CNS play an important role in driving immune response psoriasis atopic dermatitis. We examined whether blockade of sk...

Treatment of psoriasis with vitamin D3 analogues is well established in present dermatological practice. One of the clinical signs of the psoriatic plaque that reduces early and markedly during treatment with the vitamin D3 analogue calcipotriol is scaling. Since scaling is the clinical manifestation of disordered epidermal differentiation, early changes in immunohistochemical markers for diffe...

Actinic Keratoses (AKs) are premalignant intraepithelial skin lesions that can progress to cutaneous squamous cell carcinoma (SCC). The field of cancer immunotherapy has demonstrated the ability immune system treat late-stage cancers. We have shown also be leveraged prevent through a randomized, double-blind clinical trial. Topical calcipotriol plus 5-fluorouracil (5-FU) effectively eliminates ...