Ketoconazole topical is an antifungal medication. Ketoconazole topical prevents fungus from growing on your skin. The aim of the present investigation was to design and formulate an appropriate microspheres loaded gel (MLG), and explore the parameters affecting the morphology and other characteristics of the resultant products employing scanning electron microscopy (SEM). Microspheres loaded to...

Topical anesthetics play an important role in the practice of ophthalmology, both for procedures in the office and in the operating room. The need for safe, long-acting topical ocular anesthetic agents is ongoing, and has been highlighted by the increase of intravitreal administration of pharmacologic agents. Current practices for ocular anesthesia include subconjunctival injection of 2% aqueou...

BACKGROUND Brimonidine tartrate is a highly selective alpha 2 agonist that induces direct vasoconstriction of small arteries and veins, thereby reducing vasodilation and edema. OBJECTIVE To review the current literature regarding the safety, efficacy, and patient acceptability of brimonidine 0.33% gel. METHODS A PubMed search was performed using the terms brimonidine 0.33% gel, rosacea, saf...

AIM The aim of this study was to evaluate the surface/mineral changes on enamel before and after the application of acidulated phosphate fluoride (APF) gel, fluoride enhanced hydroxyapatite gel and propolis in conjunction with carbon-dioxide (CO2) laser. MATERIALS AND METHODS Crowns of 40 human maxillary central incisors were collected and were divided into four groups of 10 each: Topical flu...

BACKGROUND Topical or systemic antiviral drugs reduce the duration of genital herpes recurrences but may not always alleviate functional symptoms. OBJECTIVES To assess the efficacy and safety of oxygenated glycerol triesters-based CS21 barrier genital gel(®) vs. topical aciclovir and placebo (vehicle) in resolving functional symptoms and in healing of genital herpes recurrences. METHODS A p...

The antidiabetic properties of prosopis gum alone and as a bioadhesive base for the delivery of metformin are presented. The bioadhesive value of the gum was commensurate with those of Carbopol 974-P and sodium carboxymethyl cellulose (NaCMC). The release of the drug was higher from prosopis gum based bioadhesive formulations than from NaCMC and Carbopol 974-P products. This was shown by the sh...

Tuberculosis (TB) is an infectious disease that mainly affects the lungs. For the treatment of tuberculosis, conventional drug delivery system fails to achieve efficient drug delivery system fails to achieve efficient drug delivery at the target site. Today, bioadhesive microspheres became a topic of great interest as a novel carrier for drug delivery. Bioadhesive microspheres offers longer ret...

The present study was aimed at evaluating the possible use of inter polymer complexed (IPC) films of xanthan gum (XG) and cationic guar gum (CGG) for formulating domperidone bioadhesive films. Formation of bonds between -COO¯ groups of XG and -N(+)(CH(3))(3) groups of CGG was evident in the FTIR spectra of IPC films. Bioadhesive strength of the films was evaluated employing texture analyser. Wa...

introduction: alveolar osteitis (ao) is one of the most common postoperative complications after third molar surgery. various techniques have been used to reduce the risk of ao. the aim of the current study was to evaluate the effect of chlorhexidine (chx) bioadhesive gel in preventing the development of ao. methods: patients with bilateral impacted mandibular third molars underwent surgical ex...

BACKGROUND Poor adherence to topical therapy in psoriasis remains an issue; it is associated with poor clinical outcomes, reduced quality of life and increased costs. Treatment-related factors leading to poor adherence include lack of efficacy, excessive time applying medication and poor cosmetic characteristics (e.g. slow absorption, greasiness). OBJECTIVE To assess the topical treatment att...