PURPOSE To assess the prophylactic effect of preoperative application of topical diclofenac on postoperative pain control in patients having photorefractive keratectomy (PRK). SETTING Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. DESIGN Randomized masked clinical trial. METHODS In this paired-eye study, patients having bilateral PRK received 1 drop of diclofena...

BACKGROUND COX-2 inhibitors have an antitumor potential and have been verified by many researchers. Treatment of cancer cells with external stressors such as irradiation can stimulate the over-expression of COX-2 and possibly confer radiation resistance. In this study, we tested if topical diclofenac, which inhibits both COX-1 and COX-2, administration rendered prostate tumor cells sensitize to...

Report of a Case Awoman in her 50s presentedwith an 8-year history of an annular plaque in the left perioral area. Physical examination showeda thick hyperkeratotic annular plaque with elevated edges and an atrophic center (Figure 1).Histopathologic examinationof the lesion revealedacornoid lamella, anunderlyingepidermisdevoidof agranular layer, and a lymphocytic infiltration in the upper dermi...

REFERENCES 1. Szczeklik A. Adverse reactions to aspirin and nonsteroidal antiinflammatory drugs. Ann Allergy 1987;59:113-18. 2. Alkhawajah AM, Eifawai M, Mahmoud SF Fatal anaphyiactic reaction to diclofenac. Forensic Sci Int 1993;60:107-10. 3. Mescheder A, Nokhodian A, Kirch W. Anaphylactic shock as complication of Ml application of diclofenac. Arzneimitteltherapie 1993;11:237-9. 4. Romano A, P...

The purpose of this study was to investigate microemulsions as delivery systems for diclofenac sodium (DS). Microemulsion systems were composed of: soybean oil, nonionic surfactants (Brij 58 and Span 80), and different alcohols: ethanol, and 1-buthanol as cosurfactant. The optimum surfactant: cosurfactant (S:CoS) weight ratios and microemulsion areas were detected by the aid of ternary phase di...

The removal of diclofenac sodium ophthalmic solution as a viable pharmaceutical entity in September 1999 from the US market spurred considerable interest in the general safety and effectiveness of topical ophthalmic NSAIDs for treatment of anterior segment inflammation. In late 1999 the use of topical ocular NSAIDs declined in the US as a result of incidents involving corneal melts and toxicity...

The liposomal cream formulation of diclofenac, an NSAID, is an effective, safe, and convenient way to treat localized areas of inflammation in horses. The results of this study reveal urinary and serum concentrations of diclofenac following topical administration of 1% liposomal diclofenac cream for 10 days at the labeled dose and at 2X and 4X the labeled dose. These results demonstrate the slo...

OBJECTIVE To investigate systemic absorption and renal effects of topically applied ophthalmic flurbiprofen and diclofenac in healthy cats. ANIMALS STUDIED Twelve domestic shorthair cats. PROCEDURES Cats were randomly assigned to two treatment groups (n = 6) and administered one drop (approximately 40 μL) of either flurbiprofen 0.03% or diclofenac 0.1% in both eyes four times daily (6 am, 1...