The neo-sex chromosomes of Drosophila miranda constitute an ideal system to study the effects of recombination on patterns of genome evolution. Due to a fusion of an autosome with the Y chromosome, one homolog is transmitted clonally. Here, I compare patterns of molecular evolution of 18 protein-coding genes located on the recombining neo-X and their homologs on the nonrecombining neo-Y chromos...

Purpose – To show that the neo-pragmatist position of Richard Rorty, when combined with a sociocultural perspective, provides library and information science (LIS) with a forceful epistemological tool. Design/methodology/approach – Literature-based conceptual analysis of: historical development of pragmatism in relation to other epistemological positions; neo-pragmatism as a non-dualist, both p...

Sex chromosomes originate from pairs of autosomes that acquire controlling genes in the sex-determining cascade. Universal mechanisms apparently influence the evolution of sex chromosomes, because this chromosomal pair is characteristically heteromorphic in a broad range of organisms. To examine the pattern of initial differentiation between sex chromosomes, sequence analyses were performed on ...

Recent data suggest that T-cell reactivity against tumor-specific neo-antigens may be central to the clinical efficacy of cancer immunotherapy. The development of personalized vaccines designed to boost T-cell reactivity against patient specific neo-antigens has been proposed largely on the basis of these findings. Work from several groups has demonstrated that novel tumor-specific antigens can...

The NEO Personality Inventory-3 (NEO-PI-3) is a modification of the Revised NEO Personality Inventory (NEO-PI-R) designed to be more understandable to adolescents. Data from adults aged 21 to 91 showed that the NEO-PI-3 also functions as well or better than the NEO-PI-R in adults. Age trends from combined adolescent (n = 500) and adult (n = 635) samples confirmed previous cross-sectional findin...

Absorbing aerosols can strongly absorb solar radiation and have a profound impact on the global and regional climate. Black carbon (BC), organic carbon (OC) and dust are three major types of absorbing aerosols. In order to deepen the overall understanding of absorbing aerosols over East Asia and provide a basis for further investigation of its role in enhanced warming in drylands, the spatial-t...

Lisoněk recently reformulated the characterization of Charpin and Gong of a large class of hyper-bent functions in terms of cardinalities of hyperelliptic curves following previous ideas of Lachaud and Wolfmann, and Katz and Livné. In this paper, we present a generic approach of such ideas and show that it applies naturally to a distinct family of functions proposed by Mesnager. Doing so, a pol...

When nonmetastatic dimethylbenzanthracene-induced rat mammary cancer cells (KM( I ) were transfected with a control plasmili containing the neomycin resistance gene (i.e.. Neo/Only), none of the five clonal Neo/Only transfectants isolated and characterized was metastatic, only one of five had a single structural chromosomal abnormality, and only one of five had a single numerical chromosomal ch...

Covalent modifications of histones play an important role in chromatin architecture and dynamics. In particular, histone lysine methylation is important for transcriptional control during diverse biological processes. The nuclear protein Jmjd5 (also called Kdm8) is a histone lysine demethylase that contains a JmjC domain in the C-terminal region. In this study, we have generated Jmjd5-deficient...

The concept of a non-extreme-outcome-additive capacity (neo-additive capacity ) is introduced. Neo-additive capacities model optimistic and pessimistic attitudes towards uncertainty as observed in many experimental studies. Moreover, neo-additive capacities can be applied easily in economic problems, as we demonstrate by examples. This paper provides an axiomatisation of Choquet expected utilit...