One of the main tasks modern complex therapy rheumatoid arthritis (RA) is to improve quality life patients. To do this, it necessary not only achieve remission or low activity, but also successfully control main, most painful, manifestations disease. Therefore, when evaluating results RA treatment, dynamics standard indices (DAS28 (Disease Activity Score 28), CDAI (Clinical Disease Index), SDAI...

The aim of this study is to investigate the role of tumor necrosis factor-α (TNF-α) in apoptosis and autophagy of mouse osteoblast MC3T3-E1 cells, as well as the crosstalk between autophagy and apoptosis. Mouse osteoblast MC3T3-E1 cells were cultured in vitro and treated with 5-fluorouracil (5-FU), rapamycin, 3-methyl adenine (3-MA) and TNF-α either alone or in combination, respectively. MTT as...

background: melatonin, a reactive oxygen species (ros) scavenger and an antioxidant, has been shown that can inhibit apoptosis. administration of melatonin may improve embryo development in assisted reproductive technology (art). objective: the aim of this study was to evaluate the role of melatonin in inhibition of spontaneous and induced apoptosis by tumor necrosis factor alph (tnf-α) and act...

background and aims. the role of cytokines in the immunopathogenesis of oral lichen planus (olp) has received much attention. the aim of this study was to evaluate the serum levels of tnf-α and tgf-β in patients with olp in an iranian population. materials and methods. thirty-two patients with olp and 32 age-matched healthy volunteers as a control group were included in this study. serum tests ...

مقدمه افزایش سن، سندروم متابولیک و عوامل التهابی از عوامل موثر در کاهش حجم مغز و افت عملکرد شناختی می باشد. هدف از این تحقیق بررسی اثرگذاری 12 هفته تمرین هوازی با شدت متوسط بر bdnf و tnf-α زنان 50-65 ساله مبتلا به سندروم متابولیک می باشد. روش کار این مطالعه به روش نیم تجربی و از نوع کاربردی با طرح پیش آزمون – پس آزمون و گروه کنترل در شهر زنجان درسال 1394 انجام شده است. 24 زن مبتلا به سندروم متا...

background: in this study, the pilot production of aerobic bioreactor tropical theileriosis vaccine was optimized with the aim of immunological assays for further mass production. methods: we have shown earlier the delayed type hypersensitivity (dth) assay could be used for evaluating the immunity and memory cells against specific theileria antigen in vaccinated animals. in addition, tnf-α is t...

To study the effect of EGFR activation on the generation of TNF-α and the occurrence of cardiac dysfuncetion during sepsis, PD168393 and erlotinib (both are EGFR inhibitors) were applied to decreased the production of TNF-α and phosphrylation of ERK1/2 and p38 induced by LPS in cardiomyocytes. These results were further proved by specifically knocked down the expression of EGFR in vitro. Both T...

BACKGROUND Tumor necrosis factor-α (TNF-α) inhibitors, such as infliximab, adalimumab, and certolizumab pegol are effective agents in the treatment of inflammatory bowel disease. Some individuals undergoing anti-TNF-α therapy for Crohn's disease or ulcerative colitis develop psoriasiform lesions. This is a paradoxical finding, as classical psoriasis is known to respond to these agents. PURPOS...

A 36-year-old woman with no medical or surgical history was evaluated for weight loss. Abdominal computed tomography (CT) showed signs of Crohn's disease, which was later confirmed endoscopically. She was started on tumor necrosis factor-α (TNF-α) inhibitor therapy. Nine months after treatment, she experienced additional weight loss and a 7 x 8 x 8-cm mass on repeat CT. Biopsy revealed retroper...

Tumor Necrosis Factor (TNF)-α, is a paracrine inhibitor of melanocytes, which plays a critical role in the pathogenesis of several autoimmune diseases including vitiligo, as abnormal immune responses have frequently been observed in vitiligo patients. Moreover, vitiligo patients show higher lesion levels of TNF-α. Genetic polymorphisms in the promoter region of TNF-α are involved in the regulat...