The study evaluated the ability of 11 global climate models latest two versions Coupled Model Intercomparison Project (CMIP5 and CMIP6) to simulate observed (1965–2005) rainfall, maximum (Tmax) minimum (Tmin) temperatures, mean eastward (uas) northward (vas) wind speed, surface pressure. It also relative uncertainty in projections variables using those CMIPs. European reanalysis (ERA5) data wer...

The bioavailability of a generic diclofenac sodium sustained release tablet preparation (Zolterol, SR) was compared with the innovator product, Voltaren, SR. Twelve healthy adult male volunteers participated in the study, which was conducted according to a randomized, two-way crossover design with a wash out period of one week. The bioavailability of diclofenac was compared using the parameters...

BACKGROUND AND PURPOSE Patients with internal carotid artery (ICA) occlusion can demonstrate impaired cerebral vascular reserve (CVR). The detection of CVR using single photon emission CT (SPECT) is nowadays widely accepted as a predictor in the diagnostic pathway in patients considered for cerebral revascularization. Recently perfusion CT (PCT) gained widely acceptance in stroke imaging. The p...

Phentolamine mesylate accelerates recovery from oral soft tissue anesthesia in patients who have received local anesthetic injections containing a vasoconstrictor. The proposed mechanism is that phentolamine, an alpha-adrenergic antagonist, blocks the vasoconstriction associated with the epinephrine used in dental anesthetic formulations, thus enhancing the systemic absorption of the local anes...

ABSTRACT Air temperature significantly affects the processes involving agricultural and human activities. The knowledge of a given location is essential for planning. It also helps to make decisions regarding However, it not always possible determine this variable. necessary precise estimate, using methods that are capable detecting existing variations. aim study was develop models multiple lin...

A strategy for assessing potential drug-drug interactions (DDIs) based on a simulated intestinal concentration is described. The proposed predictionmethodwas applied to the DDI assessment of luseogliflozin, a novel antidiabetic drug, against miglitol absorbed via the intestinal sodium-glucose cotransporter 1 (SGLT1). The method involves four steps: collection of physicochemical and pharmacokine...

BACKGROUND AND PURPOSE Arterial spin labeling (ASL) is a perfusion magnetic resonance imaging (MRI) technique that does not require contrast administration and thus may be more practical in hyperacute stroke than susceptibility-weighted bolus-tracking perfusion-weighted imaging (PWI). However, a threshold for ASL measurement of the ischemic penumbra needs to be determined. METHODS A total of ...

BACKGROUND AND PURPOSE Identifying core, irreversibly infarcted tissue and salvageable penumbral tissue is crucial to informed, physiologically guided decision making regarding thrombolytic and other interventional therapies in acute ischemic stroke. Pretreatment perfusion MRI offers promise as a means to differentiate core from penumbral tissues. METHODS Diffusion-perfusion MRIs were perform...

BACKGROUND Smoking cessation can lead to changes in appetite and weight gain in some patients; thus, smoking cessation may alter gastrointestinal motility. Effects of smoking cessation on gastric emptying in smokers have not been established. AIM This study sought to determine how smoking cessation affects gastric emptying in smokers. METHODS Participant group comprised 53 habitual smokers ...