Terrestrial laser scanners (TLS) have the potential to revolutionise measurement of the three-dimensional structure of vegetation canopies for applications in ecology, hydrology and climate change. This potential has been the subject of recent research that has attempted to measure forest biophysical variables from TLS data, and make comparisons with two-dimensional data from hemispherical phot...

TLS (translocated in liposarcoma), also known as FUS (fused in sarcoma), is an RNA/DNA-binding protein that plays regulatory roles in transcription, pre-mRNA splicing and mRNA transport. Mutations in TLS are responsible for familial amyotrophic lateral sclerosis (ALS) type 6. Furthermore, TLS-containing intracellular inclusions are found in polyglutamine diseases, sporadic ALS, non-SOD1 familia...

Fused in sarcoma/translocated in liposarcoma (FUS/TLS) is one of causative genes for familial amyotrophic lateral sclerosis (ALS). In order to identify binding partners for FUS/TLS, we performed a yeast two-hybrid screening and found that protein arginine methyltransferase 1 (PRMT1) is one of binding partners primarily in the nucleus. In vitro and in vivo methylation assays showed that FUS/TLS ...

UNLABELLED DNA lesions in the template strand block synthesis by replicative DNA polymerases (Pols). Eukaryotic cells possess a number of specialized translesion synthesis (TLS) Pols with the ability to replicate through DNA lesions. The Epstein-Barr virus (EBV), a member of the herpesvirus family, infects human B cells and is maintained there as an extrachromosomal replicon, replicating once p...

TLS-ERG fusion protein is derived from the t(16;21) translocation found in human myeloid leukemia. Here, we show that retroviral transduction of TLS-ERG confers a growth advantage to L-G myeloid progenitor cells and blocks terminal differentiation. We found that the level of cyclin-dependent kinase 1 (Cdk1) protein was significantly decreased in controls but unchanged in TLS-ERG-expressing cell...

The tumor lysis syndrome (TLS), characterized by hyperkalemia, hyperuricemia, hyperphosphatemia and secondary hypocalcemia, is a consequence of treatmentinduced or spontaneous tumor cell death. It usually occurs a few hours to a few days after commencing cytotoxic chemotherapy for tumors with a high percentage of proliferating and drug-sensitive cells. Cell death leads to the release of potassi...

In this paper, transistor lasers (TLs) are used as an optical modulator for generation of ASK(Amplitude Shift Keying) and FSK (Frequency Shift Keying) optical signals. Our analysis is based on continuity equation, rate equations, and the theory of discontinuity of quasi-fermi level at the abrupt junction. Our simulation results indicate that, the specification of ASK and FSK optical signals, ar...

Terrestrial Laser Scan (TLS) data are seeing increasing use in geology, geomorphology, forestry and urban mapping. The ease of use, affordability and operational flexibility of TLS suggests that demand for it is likely to increase in large scale mapping studies. However, its advantages may remain restricted to specific environments, due to difficulties in defining bare-ground level in the prese...

Tertiary lymphoid structures (TLS) present in human solid tumors are essential for the shaping of a favorable immune micro-environment to control tumor development in most cases. They represent a formidable school for T-cell priming, B cell activation, and differentiation into plasma cells and an exquisitely located factory for antibody production. The manipulation of TLS neogenesis and mainten...

Thread level speculation (TLS) has shown great promise as a strategy for fine to medium grain automatic parallelisation, and in a hardware context techniques to ensure correct TLS behaviour are now well established. Software and virtual machine TLS designs, however, require adherence to high level language semantics, and this can impose many additional constraints on TLS behaviour, as well as o...