نتایج جستجو برای: tlr

تعداد نتایج: 8542  

Journal: :Journal of immunology 2006
Tobias Mueller Tomohiro Terada Ian M Rosenberg Oren Shibolet Daniel K Podolsky

TLRs serve important immune and nonimmune functions in human intestinal epithelial cells (IECs). Proinflammatory Th1 cytokines have been shown to promote TLR expression and function in IECs, but the effect of key Th2 cytokines (IL-4, IL-5, IL-13) on TLR signaling in IECs has not been elucidated so far. We stimulated human model IECs with Th2 cytokines and examined TLR mRNA and protein expressio...

2011
Tracy R Luckhardt Stephanie M Coomes Glenda Trujillo Joshua S Stoolman Kevin M Vannella Urvashi Bhan Carol A Wilke Thomas A Moore Galen B Toews Cory Hogaboam Bethany B Moore

Background: We have shown previously that murine gammaherpesvirus 68 (gHV68) infection exacerbates established pulmonary fibrosis. Because Toll-like receptor (TLR)-9 may be important in controlling the immune response to gHV68 infection, we examined how TLR-9 signaling effects exacerbation of fibrosis in response to viral infection, using models of bleomycinand fluorescein isothiocyanate-induce...

2011
Tracy R Luckhardt Stephanie M Coomes Glenda Trujillo Joshua S Stoolman Kevin M Vannella Urvashi Bhan Carol A Wilke Thomas A Moore Galen B Toews Cory Hogaboam Bethany B Moore

BACKGROUND We have shown previously that murine gammaherpesvirus 68 (γHV68) infection exacerbates established pulmonary fibrosis. Because Toll-like receptor (TLR)-9 may be important in controlling the immune response to γHV68 infection, we examined how TLR-9 signaling effects exacerbation of fibrosis in response to viral infection, using models of bleomycin- and fluorescein isothiocyanate-induc...

2015
Dov B. Ballak Edwin J. P. van Asseldonk Janna A. van Diepen Henry Jansen Anneke Hijmans Leo A. B. Joosten Cees J. Tack Mihai G. Netea Rinke Stienstra

Innate immunity plays a pivotal role in obesity-induced low-grade inflammation originating from adipose tissue. Key receptors of the innate immune system including Toll-like receptors-2 and -4 (TLRs) are triggered by nutrient excess to promote inflammation. The role of other TLRs in this process is largely unknown. In addition to double-stranded viral mRNA, TLR-3 can also recognize mRNA from dy...

2014
Filippo Conti Nicolas Boucherit Veronica Baldassarre Virginie Trouplin Rudolf Toman Giovanna Mottola Jean-Louis Mege Eric Ghigo

To survive in macrophages, Coxiella burnetii hijacks the activation pathway of macrophages. Recently, we have demonstrated that C. burnetii, via its lipopolysaccharide (LPS), avoids the activation of p38α-MAPK through an antagonistic engagement of Toll-like receptor (TLR)-4. We investigated the fine-tuned mechanism leading to the absence of activation of the p38α-MAPK despite TLR-4 engagement. ...

Journal: :Arthritis and rheumatism 2005
Fabia Brentano Olivier Schorr Renate E Gay Steffen Gay Diego Kyburz

OBJECTIVE To assess the expression of Toll-like receptor 3 (TLR-3) protein in synovial tissues and cultured synovial fibroblasts obtained from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) and to investigate the consequences of stimulation of cultured synovial fibroblasts with TLR-3 ligands. METHODS TLR-3 expression in synovial tissues was determined by immunohistochemistry ...

Journal: :Arthritis and rheumatism 2012
Anjali Nair Veero Kanda Charles Bush-Joseph Nikhil Verma Susan Chubinskaya Katalin Mikecz Tibor T Glant Anne-Marie Malfait Mary K Crow Greg T Spear Alison Finnegan Carla R Scanzello

OBJECTIVE Synovial inflammation, a feature of both osteoarthritis (OA) and meniscal injury, is hypothesized to be triggered in part via stimulation of Toll-like receptors (TLRs). We undertook this study to test whether a TLR-2- or TLR-4-stimulating factor in synovial fluid (SF) from patients with early knee OA with meniscal injury could lead to inflammatory activation of synoviocytes. METHODS...

Journal: :Journal of immunology 2014
Masataka Oda Hirofumi Yamamoto Masahiro Shibutani Mayo Nakano Kenta Yabiku Takafumi Tarui Naoya Kameyama Daiki Shirakawa Sumiyo Obayashi Naoyuki Watanabe Hiroshi Nakase Midori Suenaga Yoichi Matsunaga Masahiro Nagahama Hironobu Takahashi Hiroshi Imagawa Mie Kurosawa Yutaka Terao Mugio Nishizawa Jun Sakurai

Vizantin has immunostimulating properties and anticancer activity. In this study, we investigated the molecular mechanism of immune activation by vizantin. THP-1 cells treated with small interfering RNA for TLR-4 abolished vizantin-induced macrophage activation processes such as chemokine release. In addition, compared with wild-type mice, the release of MIP-1β induced by vizantin in vivo was s...

2013
Chun Wai Mai Yew Beng Kang Mallikarjuna Rao Pichika

Toll-like receptor 4 (TLR-4) is well known for its host innate immunity. Despite the fact that TLR-4 activation confers antitumor responses; emerging evidence suggests that TLR-4 is associated with tumor development and progression. It is now clear that overactivation of TLR-4, through various immune mediators, may cause immune response dysfunction, resulting in tumorigenesis. Different cancers...

Journal: :Rheumatology 2011
Arpita Myles Amita Aggarwal

OBJECTIVE Bacterial trigger possibly causes disease exacerbation in enthesitis-related arthritis (ERA) patients. Microbes initiate immune responses through Toll-like receptors (TLRs). We studied TLR expression on blood and SF monocytes and the effect of TLR ligands on peripheral blood (PB) mononuclear cells (PBMCs) in ERA patients. METHODS PB from 26 ERA patients and 19 healthy subjects and p...

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