Screening for celiac disease (CD) dramatically improved when techniques able to measure blood autoantibodies against tissue transglutaminase 2 (TTG) were developed. Although typically increased in CD, these antibodies are not pathognomonic since they are also detected in several other autoimmune processes. IgA deficiency among celiac patients is more frequent than in general population (up to 2...

Background: Celiac disease a chronic gastrointestinal disorder is caused by an immune response to the gluten. Numerous studies have been conducted worldwide on relationship between anemia and celiac disease. Objective: To find out frequency of in microcytic patients Nowshera Methodology: The current study was cross sectional carried at Gastroenterology department, Qazi Hussain Ahmad Medical Com...

Most neurodegenerative pathologies stem from the formation of aggregates of mutant proteins, causing dysfunction and ultimately neuronal death. This study was aimed at elucidating the role of the protein factors that promote aggregate formation or prevent the process, respectively, glyceraldehyde-3-dehydrogenase (GAPDH) and tissue transglutaminase (tTG) and Hsp70 molecular chaperone. The siRNA ...

BACKGROUND Celiac disease is an immune-mediated enteropathy due to a permanent sensitivity to gluten in genetically susceptible people. Iron-deficiency anemia is the most widely experienced anemia in humans. Iron-deficiency anemia additionally is a common extra intestinal manifestation of celiac disease. OBJECTIVE To investigate correlation between tTg levels and histological alterations and ...

BACKGROUND Celiac disease (CD) is an intestinal inflammatory condition that develops in genetically susceptible individuals after exposure to dietary wheat gliadin. The role of post-translational modifications of gliadin catalyzed by tissue transglutaminase (tTG) seems to play a crucial role in CD. However, it remains to be established how and where tTG is activated in vivo. We have investigate...

OBJECTIVE: To find out the clinical profile and association of Celiac Disease (CD) in children with established type-1 Diabetes Mellitus (T1DM) presenting a tertiary care hospital Karachi, Pakistan. METHODS: This cross-sectional study was conducted from January-2019 to July-2019 at National Institute Child Health, A total 126 T1DM patients age 1-18 years were subjected detailed history examinat...

BACKGROUND We prospectively evaluated the usefulness of IgA tissue transglutaminase antibodies (IgA tTG) in the initial diagnosis of celiac disease (CD) and compared its diagnostic potential with that of IgA anti-endomysial antibodies (IgA EMA) and anti-IgA and IgG gliadin antibodies (AGA and AGG, respectively). METHODS Sera of 23 untreated children fulfilling the revised ESPGHAN criteria for...

background this study aimed to explore demographic characteristics and clinical presentations of celiac disease (cd) in northeastern iran. methods this was a cross-sectional retrospective study of 193 adults with cd who presented to mashhad university gastroenterology clinic between 2008 and 2013. patient data that included mode of presentation and the presence of any concomitant illnesses were...

OBJECTIVES Several studies have indicated that adult patients with spondyloarthritis (SpA) have elevated levels of antibodies associated with celiac disease (CD). This has not been studied in children, and none of the studies corrected for total IgA levels. METHODS We measured total IgA and IgA against tissue transglutaminase (TTG) levels in 42 children with Juvenile Idiopathic Arthritis (JIA...

The aim of the study was to analyze the accuracy of (i) HLA-DQ typing and anti-tissue transglutaminase antibodies immunoglobulin A (tTG-IgA) serology and (ii) a "simple scoring system" (SSS) for the diagnosis of celiac disease (CD). The study included 91 patients with positive tTG-IgA, who had been tested for HLA-DQ. Patients were divided into 3 groups: typical CD, atypical CD, and non-CD. The ...