Metabolism is executed by an efficient, interconnected and ancient biochemical system, the metabolic network. Its evolutionary origins are, however, barely understood. We here discuss that because of niche adaptation, selection acting on network structure distinguishes modern species early life forms. Yet, its basic remained conserved over more than three billion years diverging evolution. spec...

BACKGROUND Lack of regulatory capacity limits the conduct of ethical and rigorous trials of herbal medicines in developing countries. Sharing ethical and regulatory experiences of successful herbal trials may accelerate the field while assuring human subjects protection. The methods and timelines for the ethical and regulatory review processes for the first drug regulatory authority approved he...

One of the most prevalent parameters in visualized data is time. A large part of information visualization concerns time-series data, where a progress or shift is shown over time. In this survey paper we want to look at the special case of event timelines that aim for giving an overview over a sequence of events that all belong to a superior topic. Timelines can for example show happenings in t...

The development of theories and computational models of reading requires an understanding of processing constraints, in particular of timelines related to word recognition and oculomotor control. Timelines of word recognition are usually determined with event-related potentials (ERPs) recorded under conditions of serial visual presentation (SVP) of words; timelines of oculomotor control are der...

PCG approaches are commonly categorised as constructive, generateand-test or search-based. Each of these approaches has its distinctive advantages and drawbacks. In this paper, we propose an approach to Content Generation (CG)– in particular level generation – that combines the advantages of constructive and search-based approaches thus providing a fast, flexible and reliable way of generating ...

A secure timeline is a tamper-evident historic record of the states through which a system goes throughout its operational history. Secure timelines can help us reason about the temporal ordering of system states in a provable manner. We extend secure timelines to encompass multiple, mutually distrustful services, using timeline entanglement. Timeline entanglement associates disparate timelines...

This paper reports on the design, development and evaluation of TimeViewer, a system allowing the storing, visualization and multimodal interaction with temporal and semantic information using timelines in 3D environments. We focus on the appliance of 3D interactive timelines for temporal information visualization, extending their capabilities with the novel concept of a time-tunnel. Our work i...

Research in the semantic web community has given rise to some powerful methods for visualizing events and related media—mostly in terms of interactive timelines—and for enabling users to interact with these visualizations. The present paper aims to advance this line of research in two ways: (a) by developing interactive visualizations of event hierarchies of essentially arbitrary depth and size...

The influence of serendipity is often underestimated in the information seeking process. Although serendipity has often been discussed as facilitator of inspiration and creativity, there are still very few systems that focus on supporting serendipitous discoveries. The Bohemian Bookshelf is an interface for the exploration of book collections, that is designed to systematically support serendip...