Background: Focal fibrocartilaginous dysplasia (FFCD) is a benign lesion and has been reported as a cause of tibia vara in proximal tibia and distal of the femur. It is rare in upper extremity and few cases have been reported in the ulna and radius. Objectives: The aim of the study was to review and report the clinical course, radiographic presentation and treatment results of three cases of FF...

In patients with progressive Blount`s disease early surgical treatment is advised. The recurrence following the surgical treatment of Blount`s disease has been documented. Medial tibial plateau elevation is one of the treatment in severe Blount`s disease. Clinical and radiological assessment of the knee was used for elevation of medial tibial plateau in severe tibia vara. Significant depression...

BACKGROUND Retinyl esters (REs), the major storage form of vitamin A (retinol), provide substrates for the production of bioactive retinoids, including retinoic acid (RA), which are known to promote lung development and maturation. We previously showed that the nutrient-metabolite combination VARA (molar ratio 10 vitamin A to 1 RA), synergistically increased REs in the lungs of 1-week-old rats,...

The purpose of this study was to investigate the change in patellar position after open wedge high tibial osteotomy (OWHTO) with distal tubercle osteotomy (DTO), comparing outcomes of conventional OWHTO in young adults with proximal tibia varus deformity but no arthritic manifestations. Thirty-three patients (mean age, 31.8 years) subjected to OWHTO/DTO were matched with 30 patients (mean age, ...

The ToxRS system in Vibrio cholerae plays a central role in the modulation of virulence gene expression in response to environmental stimuli. An integration of multiple signalling inputs mediated by ToxR, -S, and -T controls virulence gene expression leading to cholera toxin (CT) production. Recently, we identified a new virulence locus, varA (virulence associated regulator), in classical V. ch...

We have recently shown that a combination of vitamin A (VA) and retinoic acid (RA) in a 10:1 molar ratio (VARA) synergistically increases lung retinoid content in newborn rodents, more than either VA or RA alone in equimolar amounts. We hypothesized that the increase in lung retinoids would reduce oxidative stress and proinflammatory cytokines, resulting in attenuation of alveolar simplificatio...