The authors address the problem of downhill protein folding in the framework of a simple statistical mechanical model, which allows an exact solution for the equilibrium and a semianalytical treatment of the kinetics. Focusing on protein 1BBL, a candidate for downhill folding behavior, and comparing it to the WW domain of protein PIN1, a two-state folder of comparable size, the authors show tha...

From April 2005 all doctors in the UK will be expected to be able to demonstrate their fitness to practice as part of the GMC revalidation procedures. The revalidation process is explicitly linked to the consultant appraisal process implemented in 2001. Central to both processes is the development of a folder (portfolio) of supporting evidence. Many consultants have no experience of developing ...

Participants in face-to-face dialogue have available to them information from a variety of modalities that can help them to understand what is being communicated by a speaker. While much of the information is conveyed by the speaker’s choice of words, his/her intonational patterns, facial expressions and gestures also reflect the semantic and pragmatic content of the intended message. In many c...