Diabetic dermopathy (DD) is the most common cutaneous manifestation of diabetes mellitus. DD refers to atrophic, hyperpigmented macules characteristically located on the shins of patients with diabetes. They have an unfavorable association with the 3 most common microangiopathic complications of diabetes mellitus: neuropathy, nephropathy, and retinopathy. A relationship between DD and coronary ...

INTRODUCTION We describe an interesting patient with penicillamine-induced dermopathy. CLINICAL PICTURE A 49-year-old woman presented with a 1-year history of recurrent haemorrhagic blisters, milia and purpura over both her elbows, while on long-term penicillamine therapy (1.5 g daily) for Wilson's disease. Histologically, dermal elastin fibres were markedly reduced in the affected areas, con...

Introduction Non-contrast angiography emerges as an alternative method from contrast MRA due to the association of gadolinium based-agent with nephrogenic systemic fibrosis (NFS). A non-contrast MRA technique using gated 3D Turbo Spin Echo has been reported for various clinical applications [1][2]. Recently, a novel technique using triggered non-selective refocused 3D SPACE or called NATIVE SPA...

BACKGROUND Heavy kava use in Aboriginal communities has been linked to various health effects, including anecdotes of sudden cardiac deaths. AIMS To examine associations between kava use and potential health effects. METHODS A cross-sectional study was carried out within a kava-using east Arnhem Land Aboriginal community in tropical northern Australia. One-hundred-and-one adults who were cu...

Livedo is an ischemic dermopathy caused by vasculopathies or prothrombotic states, and characterized the violaceous lace-like mottling of skin. We report on a patient who developed livedo reticularis – racemosa overlap syndrome as late sequel erysipelas, being restricted to limb segment affected earlier erysipelas devoid systemic vasculopathy. Though are common disorders, we could not find in l...

Wrinkle-free (wrfr) is a previously uncharacterized, spontaneous, autosomal recessive mouse mutation resulting in very tight, thick skin. wrfr mutant mice exhibit severe breathing difficulties secondary to their tight skin and die shortly after birth. This phenotype is strikingly similar to a very rare human genetic disorder, restrictive dermopathy. wrfr mutant mice display a defective skin bar...