the influence of hypo- and hyper-thyroidism on spermatogenesis was studied in 60-day-old adult malewistar rats. to confirm hypo- and hyper-thyroidism, the concentration of plasma thyroid hormones wereassayed by radioimmunoassay. the hypothyroid state, induced by administration of 25 mg/kg/daymethimazole for 5 successive days, resulted in significant decrease in the number of sertoli cells, sper...

In 30 patient with single cold thyroid nodule and normal thyroid function tests, 99mTc-MIBI scan is performed. The nodules are divided to hot (10), Warm (12) and cold (8). FNA reported papillary Ca in 4, suspicious follicular neoplasm in 3 and 23 benign lesions. 7 patients were operated on and had final pathology reports (4 papillary Ca and 3 benign lesions). All the nodules with no MIBI ...

The very intimate association between the thyroid gland and sexual activity has been recognised for a long time. M'Garrison states that 50 per cent, of pregnant women show slight thyroid swelling during pregnancy?primiparai to a surprising extent. Healthy thyroidal activity is excited and maintained by marriage and child-bearing. He also states that conception is to a great extent dependent on ...

this work analyzes the effects of satureja khuzestanica essential oil (skeo) on the thyroid and antioxidant system, assessed by measuring levels of tri-iodothyronine (t3), thyroxine (t4), thyroid-stimulating hormone (tsh), malondialdehyde (mda), reduced glutathione (gsh), and glutathione peroxidase (gpx) activity. forty adult male sprague dawley rats (225 ± 25 g) were divided into five equal gr...

The investigations of ultimobranchial tissue still remain to be some contradictory questions on its fate and function. Some investigators insist the contribution of ultimobranchial tissue to formation of thyroid tissue and some others deny it. Autoradiographic studies using radioiodine (Gorbman, '47) elucidated a fact in mice that the follicles of ultimobranchial origin are not able to collect ...

Fipronil is a widely used phytosanitary product and insecticide for pets. In the rat, fipronil can disrupt thyroid function by decreasing plasma concentrations of total thyroxine (T4) likely through increased T4 clearance. However, the mechanism of fipronil action on thyroid function remains unclear. The goals of the present study were to evaluate the effects of fipronil on thyroid hormone (TH)...

In primary cultures of rat hepatocytes, specific thyroid-hormone-binding activity diminished with time and was hardly detectable at 24 h. In accordance with the loss of 3,5,3'-tri-iodothyronine (T3) binding, responses to the hormone disappeared, as indicated by low induction of the thyroid-hormone-responsive gene S14. In contrast, thyroid hormone receptor proteins were present, as determined by...

The inability to distinguish microinvasive follicular thyroid cancer from benign follicular tumors preoperatively presents an important surgical dilemma. We examined 44 follicular tumors and found telomerase activity in all 11 follicular carcinomas and in 8 of 33 benign follicular tumors. It was undetectable in 22 normal thyroid tissues adjacent to the tumors. Telomerase activity may thus provi...

1. Proteolysis of immunoglobulin G with long-acting thyroid-stimulating activity with papain and pepsin shortened the duration of thyroid stimulation in mice prepared for the McKenzie (1958) bioassay. The time-course appeared to be related to molecular size. 2. The activity after proteolysis was recovered solely in the electrophoretically slow F(ab)-fragment. 3. There was no immunological cross...

UNLABELLED Although iodinated radiopharmaceuticals usually contain a small quantity of unbound iodine, it is difficult to establish the degree to which thyroid activity on scintigraphic images reflects uptake of free radioiodine. The objective of the present study was to examine the effectiveness of thyroid blockade in subjects undergoing (123)I-meta-iodobenzylguanidine (mIBG) imaging and to es...