The ability of protein kinase from bovinepineal gland to phosphorylate calf-thymus chromatin and thereby to alter the association between chromatin DNA and histones was investigated. Phosphorylation of calf-thymus chromatin by pineal protein kinase results in an apparent decreased binding between the histones and DNA in chromatin, as indicated by (i) an increase in actinomycin D-binding sites a...

Thymus: This is a part of the immune system that is located in the anterior mediastinum. It is more prominent in children and often extends from 4th costal cartilage to the lower poles of the thyroid gland. It shrinks during adulthood and is slowly replaced by the fat tissue. The thymus plays an important role in the production and maturation of T-lymphocytes that protect the body from various ...

A 23-year-old woman with myasthenia gravis underwent thymectomy in September, 1975 by a trans-sternal approach for the removal of an hyperplastic gland. Surgical intervention was followed by marked improvement of her symptoms. Five years later, symptoms recurred. In March, 1982 diagnostic pneumomediastinum disclosed an anterosuperior mediastinal mass which, on excision, proved to be an hyperpla...

Cervical ectopic thymus occurs when thymic tissue arrests during its embryologic descent through the neck to the upper mediastinum. Most often it presents as an asymptomatic neck mass. Rarely does it present with airway compromise, particularly in neonates. A neonate presented with a retropharyngeal mass causing dynamic upper airway obstruction, mimicking a venolymphatic malformation. Ultimatel...

A case is described of primary hyperparathyroidism in a patient with both a parathyroid cyst within the thymus gland and a concomitant parathyroid adenoma. The parathyroid adenoma contained microcystic areas of degeneration, and it is thought that the parathyroid cyst reflected degenerative change in a pre-existing adenoma. Parathyroid cyst should be considered in the differential diagnosis of ...

Thymus: This is a part of the immune system that is located in the anterior mediastinum. It is more prominent in children and often extends from 4th costal cartilage to the lower poles of the thyroid gland. It shrinks during adulthood and is slowly replaced by the fat tissue. The thymus plays an important role in the production and maturation of T-lymphocytes that protect the body from various ...

Congenital osteopetrosis in the mutant rat "op" is accompanied by early atrophy of the thymus gland. The response of thymocytes to concanavalin A and phytohemagglutinin P was greatly diminished at age 28 days, even before pronounced thymic atrophy could be detected. The response of spleen cells to mitogens that stimulate thymus-derived (T) and bone-marrow-derived (B) cells was diminished as ear...

The thymus gland is a central lymphoid organ in which developing T cell precursors, known as thymocytes, undergo differentiation into distinct type of mature cells, ultimately migrating to the periphery where they exert specialized effector functions and orchestrate immune responses against tumor pathogens self-antigens. mechanisms supporting intrathymic are pleiotropically regulated by thymic ...

Introduction. Ectopic cervical thymus tissue results from incomplete migration of the thymic primordia during embryogenesis. It is asymptomatic in most cases, however, 10% patients there are different kind symptoms. Case report. A 4-month-old boy was referred to our clinic, for evaluation a growing large neck mass on right side that has been present since birth. Physical examination revealed pa...

The means by which cell nuclei obtain free energy for RNA, DNA, and protein synthesis and other processes is a question of considerable importance to our understanding of cellular physiology and function. Mitochondria are known to have a highly organized, membrane-bound system for the oxidative phosphorylation of adenosine diphosphate to adenosine triphosphate. Our observations point to the con...