OBJECTIVE The incidence and prevalence of kidney stone is increasing worldwide. After the first recurrence the risk of subsequent relapses is higher and the time period between relapses is shortened. Urinary stones can be severely painful and make a huge economic burden. The stone disease may increase the vulnerability of patients to other diseases such as renal failure. Medicinal herbs are ric...

In recent years regulation of the enzymatic activity of human neutrophil elastase (HNE) has been the main focus of investigation, due to its potential therapeutic application in medicinal field. In the present study, the docking behaviour of human neutrophil elastase (HNE) with 14 different ligands namely Chrotacumines-A, B, C, GrandolsB, D, G, Rohitukine, Quercitin, Ellagic acid, Artoindonesia...

cancer is one of the main causes of mortality in the world which appears by the effect of enviromental physico-chemical mutagen and carcinogen agents. the identification of new cytotoxic drugs with low side effects on immune system has developed as important area in new studies of immunopharmacology. thymoquinone (tq), derived from the medicinal spice nigella sativa (also called black cumin) ex...

Nigella sativa Linn. (Ranunculaceae) (N. sativa), commonly known as black seed or black cumin, is an herbaceous plant, mainly grows in the Middle East, Central Europe and Western Asia. It is widely used in indigenous system of medicine for treatment of numerous disorders for over 2 000 years[1-3]. Its seed oil had been widely used in Arab traditional of medicine for the treatment of arthritis, ...

OBJECTIVE To investigate the effects of thymoquinone (TQ) in a penicillin-induced epilepsy model in rats. METHODS This experimental study included 56 adult male Wistar rats. Experiments were performed in the Research Laboratory of the Department of Physiology, Medical School, Duzce University, Duzce, Turkey, between October 2013 and December 2014. Animals were divided into the following 7 gro...

Background: Pollution and genetic factors have increased the likelihood of cancer in developing world. Cancer is now leading cause death young patients. Scientists are focusing on new treatments with a lower risk profile than traditional cytotoxic drugs. Nigella sativa (black seed) has been used for centuries by ancient cultures to treat variety ailments. Thymoquinone, main active compound foun...

Thymoquinone (TQ), a component derived from the bioactive constituent of black seed (Nigella sativa), has been shown to exert biological activity on various types of human cancers. However, there are few studies addressing its effects on gastric cancer. Here, we present the first report describing the chemosensitizing effect of thymoquinone and 5-fluorouracil (5-FU) on gastric cancer cells both...

OBJECTIVE In previous studies the therapeutic effects of Nigella sativa have been demonstrated on asthmatic animals. In the present study, the preventive effect of single dose of alpha-hederin, its active constituent, has been evaluated on lung inflammation and some inflammatory mediators in lungs of ovalbumin sensitized rat in order to elicit its mechanism. MATERIALS AND METHODS Forty rats w...

Introduction: Arsenic, an established poisonous metalloid has widespread occurrence in the environment which is posing a constant threat to health and survival of all living organisms. In view of arsenic induced oxidative stress and toxicity, this study focuses on the mitigatory role of thymoquinone, a major active component in the volatile oil of Nigella sativa (commonly known as black cumin);...