The Trinity test of July 16, 1945, marked the scientific apex Manhattan Project. Often recognized as symbolic birth nuclear age, Trinity’s multifaceted legacy remains just capt...

Background: Fabry disease, an X-linked inborn error of glycosphingolipid catabolism, results from mutations in the a-galactosidase A (a-Gal A) gene located at Xq22.1. To determine the nature and frequency of the molecular lesions causing the classical and milder variant Fabry phenotypes and for precise carrier detection, the a-Gal A lesions in 42 unrelated Fabry hemizygotes were determined. Mat...

-In this history of numerical taxonomy since the publication in 1963of Sokal and Sneath's Principles of Numerical Taxonomy, I include reminiscences of the reactions of biologists in Britain and elsewhere. Much of the original program has proved sound. The debate on phenetic and phylogenetic classifications has been valuable, although the logical and theoretical aspects of phenetics have been gr...