The present study shows the factors that modulate the photodamage promoted by phenothiazines. Cytochrome c was irradiated with UV light for 120 min, over a pH range from 4.0 to 8.0, in the absence and in the presence of different concentrations of thioridazine (TR) and fluphenazine (FP). In the absence of phenothiazines, the maximal rate of a Soret band blue shift (nm/min) from 409 to 406 nm wa...

STUDY OBJECTIVE Antipsychotic drugs are frequently reported to cause QT prolongation and torsade de pointes. We aim to investigate the potential risk of torsade de pointes in antipsychotic overdose by assessing the QT interval with the QT nomogram. METHODS All presentations to a toxicology service between January 1987 and May 2013 were reviewed. Admissions with single ingestions of an antipsy...

The introduction of new drugs for clinical practice in recent years, has caused an increasing number of drug-induced hepatic injuries, which are currently receiving much attention because of their iatrogenic nature . As one of the approaches to the study of pathogenesis, electron microscopic studies have been undertaken. This report is concerned with an electron microscopic observation of the l...

Materials and methods Expression of key metabolic markers was assessed by immunohistochemistry in 480 prostate samples and prostate cell lines. The levels of glycolytic metabolism were assessed using commercial colorimetric assays. The effect of the MCT inhibitor and thioridazine was evaluated on cell viability by using the Sulforhodamine B assay. Finally, ultra-structural studies were performe...

Participants: Study participants consisted of patients in the United States aged 60 and receiving antipsychotic monotherapy. The following cohorts were studied: an elderly reference population (no antipsychotics: n 1,836,799), those receiving haloperidol (n 6481) or thioridazine (n 1658); all patients receiving any conventional antipsychotic monotherapy (n 11,546), clozapine (n 117), olanzapine...