Scoparia dulcis Linn. (SD) is a perennial herb that has been well studied for its antioxidant, anti-inflammatory, antidiabetic, and hepatoprotective effects. However, scientific information on SD regarding the neuropharmacological effect is limited. This study evaluated the sedative and hypnotic effect of the ethanolic extract of whole plants of Scoparia dulcis (EESD). For this purpose, the who...

The death penalty by lethal injection is a legal punishment in the United States. Sodium Thiopental, once used in the death penalty cocktail, is no longer available for use in the United States as a consequence of this association. Anesthesiologists possess knowledge of Sodium Thiopental and possible chemical alternatives. Further, lethal injection has the look and feel of a medical act thereby...

Fruits of Phoenix sylvestris Roxb. (Arecaceae) are used to treat back pain, toothache, headache, arthritis, nervous debility and as sedative. The aim of this study was to evaluate the antinociceptive and neuropharmacological activities of methanol extract of P. sylvestris fruit pulp (MEPS). The antinociceptive activity of MEPS was evaluated by heat-induced (hot plate, tail immersion test) and c...

The present report compares Thiopentone sodium and Althesin as intravenous anaesthetic agents in modified electro-convulsive therapy. The induction time with althesin and thiopentone was more or less similar. There was significantly shorter recovery period with althesin as compared to thiopentone. Early and uneventful recovery with althesin was distinct advantage over thiopentone sodium.

FIG. 1 Formulae of the drug under study. Limited supplies of two further methylated thiobarbiturates, described by Peel et al. (1959), known as B.82 and B.133 have become available. The formulae of these are shown in figure 1 and it can be seen that B.82 is the methylated form of buthalitone. B.133 is not related chemically to any thiobarbiturate in clinical use, being sodium N-methyl 5-ethyl 5...

Anesthetic exposure during pregnancy is viewed as a relatively routine medical practice. However, recent rodent studies have suggested that common anesthetic agents can damage the developing brain. Here we assessed this claim in a higher order species by exposing previously instrumented near-term pregnant sheep at gestational day 122 (+/-1) to a combination of midazolam, sodium thiopental, and ...

Sixteen clinically healthy New Zealand white rabbits of either sex were divided into 2 equal groups (I and II) of 8 animals each. Under thiopental sodium (2.5%) anaesthesia a 2 x 3 cm full-thickness abdominal wall defect in the mid-ventral abdominal wall was created and repaired with an acellular dermal graft (ADG) in all the animals of group I (test group). In animals of group II (control grou...

BACKGROUND AND OBJECTIVES There are no studies associating ventilatory mode effects on renal repercussions during pneumoperitoneum. This study aimed at evaluating pneumoperitoneum-induced renal hemodynamics and function changes in dogs under volume and pressure controlled ventilation. METHODS This study involved 16 dogs anesthetized with sodium thiopental and fentanyl, which were divided in t...