Background Endometriosis is a common gynecological disease characterized by the presence of endometrial tissue outside the uterine cavity. This disease affects approximately 10% of women in reproductive age and is associated with pelvic pain, dysmenorrhea and infertility. The theory of involvement of stem cells is a considered new hypothesis in etiology of endometriosis.The aim of this study wa...

OBJECTIVE The objective of this study is to develop and characterize in situ thermosensitive gels for the vaginal administration of sildenafil as a potential treatment of endometrial thinning occurring as a result of using clomiphene citrate for ovulation induction in women with type II eugonadotrophic anovulation. While sildenafil has shown promising results in the treatment of infertility in ...

OBJECTIVE The study aimed to investigate the efficacy of intrauterine instillation of granulocyte colony-stimulating factor (G-CSF) on the day of ovulation triggering or oocyte retrieval in infertile women with a thin endometrium. METHODS Fifty women whose endometrial thickness (EMT) was ≤8 mm at the time of triggering during at least one previous in vitro fertilization (IVF) cycle and an ind...

ostmenopausal bleeding is a serious and not uncommon clinical gynecologic occurrence that mandates evaluation. In fact, classic teaching has labeled postmenopausal bleeding as “endometrial cancer until proven otherwise.” Studies indicate that the incidence of malignancy in such patients ranges from 1% to 14%, and obviously this rate will vary depending on the years since menopause and the class...

UNLABELLED In our study we investigated immunohistochemical expression of retinoblastoma protein (pRb) in physiological endometrium (n = 15), hyperplastic endometrium (n = 61) and post-hormone replacement therapy (HRT) endometrium (n = 24). METHODS We performed an immunohistochemical analysis of pRb expression in 100 specimens of human endometrium. RESULTS The average pRb immunoexpression i...