نتایج جستجو برای: thiazolidinediones
تعداد نتایج: 2045 فیلتر نتایج به سال:
The thiazolidinediones pioglitazone and rosiglitazone were introduced into global markets in 1999–2000; we now have over 10 years of experience with them. The safety issues that it was fashionable to focus on at that time were abnormalities of liver function as a result of the rare but serious side effects of troglitazone, the thiazolidinedione then on the market. This turned out to be irrelave...
Thiazolidinediones (TZDs), also known as Glitazones, have anti-diabetic, anti-inflammatory and anti-cancer properties. A simple, efficient cost-effective synthesis of a thiazolidinedione compound library was developed. The is facilitated by microwave irradiation in three the four steps followed reduction under pressurized hydrogen gas using palladium hydroxide. All reactions, except one, were c...
BACKGROUND Patients with type 2 diabetes have a 40% increased risk of bladder cancer. Thiazolidinediones, especially pioglitazone, may increase the risk. We conducted a systematic review and meta-analysis to evaluate the risk of bladder cancer among adults with type 2 diabetes taking thiazolidinediones. METHODS We searched key biomedical databases (including MEDLINE, Embase and Scopus) and so...
BACKGROUND Given the increase in medications for type 2 diabetes mellitus, clinicians and patients need information about their effectiveness and safety to make informed choices. PURPOSE To summarize the benefits and harms of metformin, second-generation sulfonylureas, thiazolidinediones, meglitinides, dipeptidyl peptidase-4 (DPP-4) inhibitors, and glucagon-like peptide-1 receptor agonists, a...
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