background: thiamine (vitb1) is a vitamin with various important physiological functions and postulated therapeutic effects.  its use as an analgesic in neuropathic pain has been undergoing in clinical settings. however, there has been little experimental investigation on this effect. in this study, anti-nociceptive and anti-inflammatory effects of thiamine were investigated in mice. methods: t...

To clarify the effect of thiamine on serotonin-related metabolism in magnesium-deficient rats, in vivo and in vitro experiments were carried out. In thiamine-excess magnesium-deficient and thiamine-adequate magnesium-deficient rats, serotonin oxidation activity in liver and stomach decreased significantly, while a decrease was not observed in thiamine-deficient magnesium-deficient rats. In vitr...

thiamine responsive megaloblastic anemia in didmoa (wolfram) syndrome has an autosomal- recessive mode of inheritance . megaloblastic anemia and sideroblastic anemia is accompanied by diabetes insipidus (di), diabetes mellitus (dm) ,optic atrophy (oa) and deafness (d). neutropenia and thrombocytopenia are also present. we report a 7 month old girl with congenital macrocytic anemia a rare clinic...

a pot experiment was conducted to evaluate the effect of foliar spray of salicylic acid (0, 50, 100 ppm), ascorbic acid (0, 100, 200 ppm) and thiamine (0, 50, 100 ppm) on vegetative growth, flowering and photosynthetic pigments of marigold (calendula officinalis l.) plants at greenhouse of sb university of kerman, iran. results showed that application of salicylic acid and thiamine increased nu...

In Escherichia coli, thiamine pyrophosphate is synthesized from thiamine monophosphate. Free thiamine is not involved as an intermediate in de novo synthesis of thiamine pyrophosphate.

a mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold. in this study, a derivative spectrophotometric method based on zero-crossing technique was proposed for simultaneous determination of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride. determination of these drugs was perf...

The activities of pyruvate and 2-oxoglutarate dehydrogenases were determined by a spectrophotometric method according to Massey, that of transketolase deter mined by Racker's method. The values of enzyme activity as well as the thiamine contents in the preparations were compared with those of the animals whose deficiencies were restored by thiamine administration. The thiamine deprivation resul...

BACKGROUND Thiamine deficiency has suggested to be linked to several insulin-resistance complications. In this study, we aim to associate circulating thiamine levels among cardiometabolic parameters in an Arab cohort using a simple, sensitive, rapid and selective high-performance liquid chromatography (HPLC) method that has recently been developed. METHODS A total of 236 randomly selected, co...

In the course of various investigations of microorganisms in spray-dried whole-egg powder, it became apparent that further information concerning the nutrition and metabolism of the genus Salmonella was essential. A survey of the literature revealed that little attention has been given this genus in this respect. Such information would be of value in improving the present methods of isolation a...

Thiamine transporter-2 deficiency is caused by mutations in the SLC19A3 gene. As opposed to other causes of Leigh syndrome, early administration of thiamine and biotin has a dramatic and immediate clinical effect. New biochemical markers are needed to aid in early diagnosis and timely therapeutic intervention. Thiamine derivatives were analysed by high performance liquid chromatography in 106 w...