A typical thread in research relies on the maturing of ideasthrough an iterative process of construction, testing and refinement.In this talk I will trace some such trajectories of ideas by illustrationfrom some of my own and others’ experiences in agent-based modelling.I draw inspiration from previous commentaries, including from thosewho generated the mottos: “No Notation ...

In bacteria, a fundamental level of gene regulation occurs by competitive association of promoter-specificity factors called sigmas with RNA polymerase (RNAP). This sigma cycle paradigm underpins much of our understanding of all transcriptional regulation. Here, we review recent challenges to the sigma cycle paradigm in the context of its essential features and of the structural basis of sigma ...

Previous studies in mice have demonstrated antagonistic effects of telomerase loss on carcinogenesis. Telomere attrition can promote genome instability, thereby stimulating initiation of early-stage cancers, but can also inhibit tumorigenesis by promoting permanent cell growth arrest or death. Human cancers likely develop in cell lineages with low levels of telomerase, leading to telomere losse...