The thermosensitive growth phenotype exerted by runaway-mutant plasmids was suppressed by sublethal doses of the DNA gyrase inhibitors novobiocin or nalidixic acid, although the latter drug was less efficient. A novobiocin-resistant gyrB mutant Escherichia coli strain prevented expression of the runaway phenotype at 37 to 42 degrees C in the absence of any drug.

The aim of the present study was to formulate and evaluate nystatin containing thermosensitive mucoadhesive gel for vaginal drug delivery to achieve prolonging the residence time, sustained drug release, enhancing efficacy, decreasing recurrence, and increasing patient compliance in the treatment for vaginal candidiasis. Here nystatin (1%) as a model drug. A 3 full factorial design was employed...

Injectable Hydrogels In article number 2206554, Lin Yu and co-workers develop an injectable thermosensitive hydrogel with inherent long-acting NO-releasing capacity. The system loaded β-lapachone CuCys nanoparticles can synchronously boost intracellular reactive oxygen species nitrogen levels, thereby synergistically enhancing the anti-tumor efficacy. This is suitable as a platform for extendin...

Abstract Central nervous system (CNS) injuries such as stroke or trauma can lead to long-lasting disability, and there is no currently accepted treatment regenerate functional CNS tissue after injury. Hydrogels mimic the neural extracellular matrix by providing a suitable 3D structure mechanical properties have shown great promise in regeneration. Here we present successful synthesis of thermos...

BACKGROUND Amphiphilic poly(N-isopropylacrylamide)-block-poly(ε-caprolactone) (PNiPAAm-b-PCL) copolymers were synthesized by ring-opening polymerization to form thermosensitive micelles as nanocarriers for bioimaging and carboplatin delivery. RESULTS The critical micelle concentration increased from 1.8 to 3.5 mg/l following the decrease of the PNiPAAm chain length. The copolymers revealed a ...

We have isolated suppressors (tsr1 to tsr5) of the thermosensitive growth of the scr2.II-13 mutation, which affects the stability of the signal recognition particle. The growth of these mutants is largely affected in the SCR2 context at 34 degrees C. We have studied the synthesis and secretion of an alkaline extracellular protease (AEP) in both wild-type and tsr1-1(SCR2(+)) thermosensitive muta...

The drug delivery system in breast cancer therapy with the thermosensitive hydrogel method developed significantly due to influence of availability various polymers which have characteristics that are affected by changes temperature. Drug release from gel preparations has advantages over traditional intravenous release. Despite fact injectable capability gradual and sustained release, is unpred...

The feasibility of heat engines, coupled with an internal combustion engine and designed to increase the coefficient of efficiency of hydrocarbon or other chemical fuels, was considered. The prospects of the use of osmotic phenomena in aqueous solutions of thermosensitive polymers in order to improve the operation of heat engines were shown.

An alamarBlue-based growth inhibition assay has been adapted for the thermosensitive and slow-growing pathogen Mycobacterium ulcerans. The standardized test procedure enables medium-throughput screening of preselected compound libraries. Testing of a set of 48 azoles with known antifungal activity led to the identification of an imidazole antifungal displaying an inhibitory dose (ID) of 9 μM fo...

A simple and versatile dendrimer based platform to deliver therapeutic agents at temperatures within the physiological range, is reported. Lipoic acid conjugated at the periphery of the thermosensitive dendrimer formulations undergoes slow and sustained release at 37-42 °C, and rescues the cells from oxidative stress and a pro-inflammatory endotoxic agent.