We demonstrate the feasibility of temperature-sensitive polymers as novel matrices for capillary and slab electrophoresis of DNA. These matrices combine the case-of-use of agarose with resolution properties of polyacrylamide. Two classes of matrices are used: (i) aqueous suspensions of gel microspheres and (ii) solutions containing uncross-linked temperature-sensitive polymers. When heated, the...

The present study deals with formulation and evaluation of flexible liposome embedded thermoreversible in situ intranasal gel rizatriptan benzoate. liposomes were formulated (F1-F9) optimized respect to percentage ethanol phospholipid get optimum vesicle size entrapment efficiency. vesicles characterized for their size, shape zeta potential. stable incorporated into gel. ex vivo permeation drug...

multiple traveling salesman problem (mtsp) is one of the most popular operation research problem and is known as combinatorial optimization problems. mtsp is an extension version of the famous and widely used problem named traveling salesman problem (tsp). because of its benefices in various domains, many researchers have tried to solve that, and many methods have proposed so far. mtsp is a np-...

The thermoreversible fcc-bcc transition in concentrated block copolymer micellar solutions is shown to be driven by decreases in the aggregation number as the solvent penetrates the core, leading to a softer intermicelle potential. Small-angle neutron scattering measurements in a dilute solution are used to quantify the temperature-dependent micellar characteristics. The observed phase boundary...

Mucosa-adhesive gels can be used as a useful mean of delivering drugs to or via mucosal membranes, and in particular buccal mucosa. Carbomers are among the best mucosa-adhesive materials known. The aim of this study was to compare the results obtained from the mucosa-adhesive strength of aqueous gels containing Carbomers, either alone or in combination, to the data obtained from assessing the d...

purpose our study aims to investigate the effectiveness of other treatment methods for burn related scarring and to determine the possibility of their routine administration in similar clinical settings. methods through a prospective study, 66 patients were enrolled to receive either the conventional pressure garment therapy (pgt) and silicone (control group) or exercise and physiotherapy (case...