Natural products are a rich resource for the discovery of therapeutic substances. By directly using 504 fine fractions from isolated traditional Chinese medicine plants, we performed a transgenic zebrafish based screen for anti-angiogenesis substances. One fraction, DYVE-D3, was found to inhibit the growth of intersegmental vessels in the zebrafish vasculature. Bioassay-guided isolation of DYVE...

The dopamine hypothesis of drug reward remains a difficult area of research and perhaps a major problem and hindrance to progress in unraveling the biology of addiction. Pharmacological treatment of drug dependency has been disappointing and new therapeutic targets and hypotheses are needed. Since there is accumulating evidence indicating a central role of endocannabinoid physiological control ...

the health and therapeutic employees are facing with some particular hazards. the existing insurance system has a lot of different shortcomings. determination of the frequency and type of accidents in a hospital was the main objective. all accidents were recorded and the study period was divided in to 3 periods. the victims who reported their accident were classified from personality point of v...

Purpose: The purpose of this study was to investigate the cause acute fatal poisoning and time death by analyzing National Emergency Department Information System (NEDIS) South Korea. Methods: NEDIS data from 2014 2018 excluding non-medical visits were used for study. patients with extracted using diagnostic codes. toxic substances classified into pharmaceuticals, pesticides, gases, artificial ...

Posttraumatic stress disorder (PTSD) symptoms and substance use have been associated with increased suicide ideation, but have rarely been examinedwithin a larger theoretical context of suicide risk. The interpersonal theory of suicide posits that feeling disconnected from others (i.e., thwarted belongingness) and feeling like a burden on others (i.e., perceived burdensomeness) are associated w...

fuller, in 1989, described probiotic microorganisms as “a live microbial feed supplement,which beneficially affects the host animal, by improving its intestinal microbial balance”.saccharomyces cerevisiae var. boulardii (s.boulardii) is an accurate probiotic yeast idol.the detection and budding of s.boulardiiis firmly related to the impression of healthinessto promote microorganisms from foodst...

Whereas thin melanomas have an excellent prognosis after sufficient surgical treatment, melanoma disease in advanced stages is still a therapeutic challenge. After decades of frustrating studies, new therapeutic strategies have come up in the past few years. On the one hand, increasing insights into the molecular aberrations in melanoma have led to specific "targeted" therapies to affect only t...

A working party (WP) from the Australasian Association of Clinical Biochemists, Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Royal College of Pathologists of Australasia and Royal Australasian College of Physicians recommends the following: *mass units should be used for reporting therapeutic drug concentrations in Australia and New Zealand; and the litre...

objectives this study examined the frequency of using alcohol and substances among students of islamic azad university in zahedan in 2012. patients and methods this cross-sectional study included 1,014 students studying at the islamic azad university, zahedan, using cluster sampling and distribution based on gender, college, and graduate level using the high-risk behaviors questionnaire. demogr...

alzheimer disease (ad) is a neurodegenerative disorder marked by cognitive and behavioral impairment. amyloid beta (aβ) peptides are involved in ad as the main component of amyloid plaques found in the brain. recent in vivo and in vitro studies have shown that there is a lot of substances that alter aβ pathogenesis of ad. aβ induces toxicity lead to increasing ros. in the other hand, 5-ht6 and ...