نتایج جستجو برای: therapeutic approaches

تعداد نتایج: 759391  

2006
Hans-Wolfgang Klafki Matthias Staufenbiel Johannes Kornhuber Jens Wiltfang

Alzheimer’s disease is an age-related progressive neurodegenerative disorder with an enormous unmet medical need. It is the most common form of dementia affecting 5% of adults over 65 years. In view of our ageing society the number of patients, as well as the economical and social impact, is expected to grow dramatically in the future. Currently available medications appear to be able to produc...

2017
Sepehr Feizi Amir A. Azari Sharareh Safapour

Angiogenesis refers to new blood vessels that originate from pre-existing vascular structures. Corneal neovascularization which can lead to compromised visual acuity occurs in a wide variety of corneal pathologies. A large subset of measures has been advocated to prevent and/or treat corneal neovascularization with varying degrees of success. These approaches include topical corticosteroid admi...

2017
Shweta Joshi Alok R. Singh Lisa L.R. Hartman Muamera Zulcic Hyunah Ahn Donald L. Durden

2004
Jon H Robertson Craig Clark

This book is published as one of a series entitled Foundations ofNeurological Surgery and is a clearly produced volume. The early sections on laser types and laser physics read easily and are well illustrated, but the one which follows on the interaction oflaser light with neural tissue is a little less clear but quite comprehensive. The section on benign supratentorial tumours is more of a mat...

2005
Patricio I. Meneses Erle S. Robertson

*Correspondence: Patricio I. Meneses and Erle S. Robertson, University of Pennsylvania School of Medicine, Department of Microbiology and Tumor Virology Program of the Abramson Cancer Center, 202A Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19145; e-mail: [email protected], [email protected]

Journal: :Journal of thrombosis and haemostasis : JTH 2005
D R Phillips P B Conley U Sinha P Andre

The current standard of care for the treatment of arterial thrombosis includes anticoagulants and three classes of antiplatelet agents--aspirin, thienopyridines and glycoprotein IIb-IIIa antagonists. Although these drugs have had a significant impact on morbidity and mortality in several patient populations, up to 15% of the high risk patients with acute coronary syndrome continue to suffer fro...

2012
Rohit Aggarwal Chester V Oddis

Correspondence: Rohit Aggarwal UPMC Arthritis and Autoimmunity Clinic, Department of Medicine, Rheumatology, University of Pittsburgh, Falk Medical Building, 3601 Fifth Avenue, Suite 2B, Pittsburgh, PA 15213, USA Tel +1 412 648 9782 Fax +1 412 383 8864 Email [email protected] Abstract: The idiopathic inflammatory myopathies are a heterogeneous group of diseases that include dermatomyositis (DM...

2015
Andrea Bartuli Marina Macchiaiolo Ippolita Rana Paola Sabrina Buonuomo

Familial Hypercholesterolemia (FH) is caused by a mutation in the gene that encodes the low-density lipoprotein (LDL) receptor, resulting in very high levels of circulating LDL-cholesterol and endothelial damage during time. Apoprotein B, activated by LDL receptor, and PCSK9 (proprotein convertase subtilisin / kexin type 9 serine Protease), that impairs the clearance of LDL receptors, are impor...

2014
Claudia Della Corte Valerio Nobili

In the last three decades in the United States the prevalence of overweight/obesity in pediatric population has more than tripled, causing the onset also in pediatric age of diseases previously considered exclusively of adults, such as metabolic syndrome (MetS) [1]. MetS represents a cluster of cardiometabolic abnormalities, including visceral obesity, dyslipidemia, hypertension and diabetes me...

2012
Arsenio M. Fialho Prabhakar Salunkhe Sunil Manna Sidharth Mahali Ananda M. Chakrabarty

The current therapy for glioblastoma multiforme involves total surgical resection followed by combination of radiation therapy and temozolomide. Unfortunately, the efficacy for such current therapy is limited, and newer approaches are sorely needed to treat this deadly disease. We have recently described the isolation of bacterial proteins and peptides with anticancer activity. In phase I human...

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