We previously reported that mice deficient in stearoyl-CoA desaturase-1 (Scd1) and maintained on a very low-fat (VLF) diet for 10 days developed severe loss of body weight, hypoglycemia, hypercholesterolemia, and many cholestasis-like phenotypes. To better understand the metabolic changes associated with these phenotypes, we performed microarray analysis of hepatic gene expression in chow- and ...

We assessed the convergent validity of commonly applied metrics of cerebral autoregulation (CA) to determine the extent to which the metrics can be used interchangeably. To examine between-subject relationships among low-frequency (LF; 0.07-0.2 Hz) and very-low-frequency (VLF; 0.02-0.07 Hz) transfer function coherence, phase, gain, and normalized gain, we performed retrospective transfer functi...

[1] We present detailed observations of the onset of amplitude saturation in ELF/VLF waves generated via modulated HF heating of naturally-forming, large-scale current systems, such as the auroral electrojet. Broadband ELF/VLF measurements at a ground-based receiver located near the High-Frequency Active Auroral Research Program (HAARP) HF transmitter in Gakona, Alaska, exhibit variations in si...

[1] Ionospheric effects of energetic electron precipitation induced by controlled injection of VLF signals from a ground based transmitter are observed via subionospheric VLF remote sensing. The 21.4 kHz NPM transmitter in Lualualei, Hawaii is keyed ON-OFF in 30 minute periodic sequences. The same periodicity is observed in the amplitude and phase of the sub ionospherically propagating signals ...

AIMS In endothelial cells, caveolin-1 (cav-1) is known to negatively modulate the activation of endothelial nitric oxide synthase, a key regulator of blood pressure (BP). However, the impact of genetic alteration of cav-1 on vascular nitric oxide (NO) production and BP homeostasis in vivo is unknown. METHODS AND RESULTS We used spectral analysis of systolic blood pressure (SBP) variability in...

Ð The living organism is constantly affected by natural electromagnetic influences covering a wide range of frequencies and amplitudes. One of these influences, with frequencies in the very low frequency (VLF) range, (1-100 kHz) is represented by a phenomenon called VLF-atmospherics or VLF-sferics. Sferics are very short, weak, and dampened electromagnetic impulses generated by atmospheric disc...

We examined the effects of spontaneous or evoked episodes of rhythmic activity on synaptic transmission in several spinal pathways of embryonic day 9-12 chick embryos. We compared the amplitude of synaptic potentials evoked by stimulation of the ventrolateral funiculus (VLF), the dorsal or ventral roots, before and after episodes of activity. With the exception of the short-latency responses ev...

[1] In order to make best use of the opportunities provided by space missions such as the Radiation Belt Storm Probes, we determine the response of complementary subionospheric radiowave propagation measurements (VLF), riometer absorption measurements, cosmic noise absorption, and GPS-produced total electron content (vTEC) to different energetic electron precipitation (EEP). We model the relati...

As the total amount of data measured by scientific spacecraft is drastically increasing, it is necessary for researchers to develop new computation methods for efficient analysis of these enormous datasets. In the present study, we propose a new algorithm for similar data retrieval. We first discuss key descriptors that represent characteristics of the VLF/ELF waves observed by the Akebono spac...

BACKGROUND We studied 715 patients 2 weeks after myocardial infarction to establish the associations between six frequency domain measures of heart period variability (HPV) and mortality during 4 years of follow-up. METHODS AND RESULTS Each measure of HPV had a significant and at least moderately strong univariate association with all-cause mortality, cardiac death, and arrhythmic death. Powe...