When normal plasma is exposed to foreign surfaces, Hageman factor (HF, factor XII) is activated; under appropriate circumstances, it then initiates reactions leading to coagulation, fibrinolysis, increased vascular permeability, esterolytic activity, and kinin formation. However, coagulation, fibrinolysis, and increased vascular permeability were impaired in plasma from an individual with Fletc...

We report results of long timescale adaptive kinetic Monte Carlo simulations aimed at identifying possible molecular reordering processes on both proton-disordered and ordered (Fletcher) basal plane (0001) surfaces of hexagonal ice. The simulations are based on a force field for flexible molecules and span a time interval of up to 50 μs at a temperature of 100 K, which represents a lower bound ...

As the reader might appreciate after reading Fletcher's 1953 views, in 1918 Fletcher had taken on the toughest problem of all: to quantify and model how we hear and understand speech. This understanding allowed AT&T Bell Labs engineers to develop the necessary specifications of what was to become the largest telephone network in the world. The problems that Fletcher and his colleagues studied w...

Since the original description (1) in 1850 of "vitiligoidea" in association with chronic jaundice and diabetes, it has become apparent that lipid containing fibrous masses, now called xanthomata, may appear in the skin and occasionally other tissues in many disorders of lipid metabolism (2). The commonest form, xanthoma of the eyelids (xanthelasma), and some of the rarer disseminated types may ...