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Current in vivo methods for imaging the visual cortex lack the ability to map response properties at the level of single cells. A new technique using two-photon imaging of calcium signals has now overcome this limitation.

Previous work has suggested a role for retrograde synaptic signaling via endogenous cannabinoids in regulating the inhibitory control of neuronal activity. In this issue of Neuron, Chevaleyre and Castillo provide evidence for another form of endocannabinoid-mediated depression of hippocampal inhibition, which is activity dependent and long lasting.