The progress in the development of DPI technology has boosted the use of sensitive drug molecules for lung diseases. However, delivery of these molecules from conventional DPI to the active site still poses a challenge with respect to deposition efficiency in the lung. At same time, serious systemic side effects of drugs have become a cause for concern. The developed budesonide loaded biopolyme...

Monitoring enzyme secretion in tissue culture has proved challenging because to date the activity cannot be continuously measured in situ. In this Letter, we present a solution using biopolymer loaded photonic crystals of anodized silicon. Shifts in the optical response by proteolytic degradation of the biopolymer provide label-free sensing with unprecedented low detection limits (1 pg) and cal...

the aim of this work was to optimize the coagulation-flocculation (cf) process applied tomunicipal wastewaters (ww). optimization of cf was performed to minimize chemical oxygen demand(cod), turbidity, sludge produced, and some metals in sludge. a box-behnken design was used to evaluate the effects and interactions of three factors such as type of biopolymer (guar, mesquite seed gum and opuntia...

the current study is an attempt to contribute for efficient and cost-effective substrates for xanthan gum production. in this context, the sugar cane molasses wastes can be used as a cheap substrate for xanthan gum production. xanthan biopolymer production by a novel xanthomonas campestris strain ibrc-m 10644 was optimized with statistical approaches. based on the results of response surface me...

MOTIVATION Most existing bioinformatics methods are limited to making point estimates of one variable, e.g. the optimal alignment, with fixed input values for all other variables, e.g. gap penalties and scoring matrices. While the requirement to specify parameters remains one of the more vexing issues in bioinformatics, it is a reflection of a larger issue: the need to broaden the view on stati...

Following recent x-ray diffraction experiments by Wong, Li, and Safinya on biopolymer gels, we apply Onsager excluded volume theory to a nematic mixture of rigid rods and strong " pi/2" cross-linkers obtaining a long-ranged, highly anisotropic depletion attraction between the linkers. This attraction leads to breakdown of the percolation theory for this class of gels, to breakdown of Onsager's ...

DIFFUSION OF NANOPARTICLES IN SYNTHETIC AND BIOPOLYMERSOLUTIONSbyINDERMEET KOHLIAUGUST 2013 Advisor: Dr. Ashis Mukhopadhyay

The current study is an attempt to contribute for efficient and cost-effective substrates for xanthan gum production. In this context, the sugar cane molasses wastes can be used as a cheap substrate for xanthan gum production. Xanthan biopolymer production by a novel Xanthomonas campestris strain IBRC-M 10644 was optimized with statistical approaches. Based on the results ...

Cell sheet-mediated tissue regeneration is a promising approach for corneal reconstruction. However, the fragility of bioengineered corneal endothelial cell (CEC) monolayers allows us to take advantage of cross-linked porous gelatin hydrogels as cell sheet carriers for intraocular delivery. The aim of this study was to further investigate the effects of biopolymer concentrations (5-15 wt%) on t...

Cells and tissues are mechanical as well as biochemical machines, and cellular response to mechanical cues can have as large an influence on structure and function as chemical signals. The mechanical properties of cells are largely determined by networks of semiflexible polymers forming the cytoskeleton, which has viscoelastic properties that differ in important ways from the viscoelasticity of...