BACKGROUND Our aim was to compare common carotid mean wall thickness (MWT) measurements by 3.0-T MRI with B-mode ultrasound common carotid intima-media thickness (CCIMT) measurements, a validated surrogate marker for cardiovascular disease. METHODS AND RESULTS B-mode ultrasound and 3.0-T MRI scans of the left and right common carotid arteries were repeated 3 times in 15 healthy younger volunt...

OVER THE LAST 15 YEARS, MAJOR EPIDEMIOLOGICAL STUDIES HAVE HIGHLIGHTED THE PREVALENCE OF SLEEPINESS AND SLEEP DISORDERS AMONG general population.1-3 Sleepiness at the wheel2,4 has been identified as one of the major reasons for highway accidents and fatal crashes. Patients with obstructive sleep apnea syndrome (OSAS) have a much higher risk of accidents than drivers without nocturnal breathing ...

Rats were administered nicotine (0.3 mg/kg) for 11 consecutive days before and after an electrolytic medial frontal cortex lesion. Behavioral testing was arranged so that the rats were tested on the RAM 1 day after drug administration followed by behavioral testing on the MWT 19 days after drug treatment, or tested on the MWT 1 day after drug administration followed by testing on the RAM4 days ...

Sex differences are prominent influences on spatial performance. One of the most common tasks to assess sex differences in spatial navigation in rodents is the Morris water task (MWT). In this task rats swim in a pool of water to locate a hidden platform employing the topographical relationships among the distal visual cues, pool wall, and goal location. Some evidence suggests that male rats di...

Traditional neuropsychological tests of visual and verbal memory have been used to evaluate memory deficits in schizophrenia. However, these tests cannot be used in non-human animal research, which is important for the discovery of treatments that will improve cognition and for study of the etiology of schizophrenia. To help bridge the gap between human and non-human animal research on hippocam...

TOPIC: Sleep Disorders TYPE: Original Investigations PURPOSE: Sodium oxybate is efficacious across multiple narcolepsy symptom domains, including excessive daytime sleepiness; currently approved formulations require twice-nightly dosing. The efficacy and safety of FT218, an investigational, extended-release formulation once-nightly sodium (ON-SXB), were analyzed in adults with the pivotal REST-...

Harpagophytum procumbens, also known as Devil's Claw, has historically been used to treat a wide range of conditions, including pain and arthritis. The study was designed to investigate whether H. procumbens extracts exhibit analgesic effects in plantar incision and spared nerve injury (SNI) rats. The whole procedure was performed on male SD rats. To evaluate pain-related behavior, we performed...

The current study was designed to investigate whether edible brown seaweed Ecklonia cava extracts exhibits analgesic effects in plantar incision and spared nerve injury (SNI) rats. To evaluate pain-related behavior, we performed the mechanical withdrawal threshold (MWT) and thermal hypersensitivity tests measured by von Frey filaments and a hot/cold plate analgesia meter. Pain-related behavior ...