and Applied Analysis 3 Define a function m t by m t v t ∫ t 0 g s v s ds v t ∫ t 0 g s ds, 2.5 then m 0 v 0 u0, v t ≤ m t , v′ t ≤ f t m t , 2.6 m′ t 2g t v t v′ t ( 1 ∫ t 0 g s ds ) ≤ m t [ 2g t f t ( 1 ∫ t 0 g s ds )] . 2.7 Integrating 2.7 from 0 to t, we have m t ≤ u0 exp (∫ t 0 ( 2g s f s ( 1 ∫ s 0 g σ dσ )) ds ) . 2.8 Using 2.8 in 2.6 , we obtain v′ t ≤ u0f t exp (∫ t 0 ( 2g s f s ( 1 ∫ s ...

The 4A11 antigen is a unique cytokine-inducible antigen up-regulated on rheumatoid arthritis (RA) synovial endothelial cells (ECs) compared with normal ECs. Previously, we showed that in soluble form, this antigen, Lewis(y)-6/H-5-2 (Le(y)/H) or its glucose analog, 2-fucosyl lactose (H-2g), induced the expression of EC intercellular adhesion molecule-1 (ICAM-1) and leukocyte-endothelial adhesion...

We show that for any infinite countable group G and for any free Borel action G y X there exists an equivariant class-bijective Borel map from X to the free part Free(2G) of the 2-shift G y 2G. This implies that any Borel structurability which holds for the equivalence relation generated by Gy Free(2G) must hold a fortiori for all equivalence relations coming from free Borel actions of G. A rel...

Growing evidences show that matrix metalloproteinase-1 (MMP1) plays important roles in tumorigenesis and cancer metastasis. The interactions between MMP1-1607 1G>2G polymorphism and risk of gastric cancer (GC) have been reported, but results remained ambiguous. To determine the association between MMP1-1607 1G>2G polymorphism and risk of GC, we conducted a meta-analysis and identified the outco...

BACKGROUND & AIMS We have previously reported the antifibrotic effect of dietary nucleotides in cirrhotic rats. In this work, we used primary rat hepatocytes, a liver stellate cell line (CFSC-2G) and co-cultures of both cell types to investigate the effects of exogenous nucleosides on the gene expression of various extracellular matrix components and on markers of liver function, and to ascerta...

The increased deposition of extracellular matrix by hepatic stellate cells following liver injury, in a process known as activation, is considered a key mechanism for increased collagen content of liver during the development of liver fibrosis. We report that N-(methylamino)isobutyric acid (MeAIB), a specific inhibitor of System A-mediated amino acid uptake, reduces the accumulation of collagen...

The association between MMP1 -1607 1G>2G polymorphism and cancer risk has been reported, but results remained controversial and ambiguous. To assess the association between MMP1 -1607 1G>2G polymorphism and cancer risk, a meta-analysis was performed. Based on comprehensive searches of the PubMed, Elsevier Science Direct, Excerpta Medica Database (Embase), and Chinese Biomedical Literature Datab...

In this note, we study the distribution of closed geodesics in homology on a finite area hyperbolic surface. We obtain an estimate which is uniform as the homology class varies, refining an asymptotic formula due to C. Epstein. 0. Introduction Let M be a finite area hyperbolic surface, i.e., the quotient of the hyperbolic plane H by the free action of a group of isometries such that the fundame...