An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method was developed and validated for the simultaneous determination of Delta(9)-tetrahydrocannabinol (THC), 11-hydroxy-Delta(9)-tetrahydrocannabinol (11-OH-THC), and 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol (THC-COOH) in whole blood. Samples were prepared by protein precipitation followed by solid-phase ext...

Human osteosarcoma is considered a malignant tumor with poor prognosis that readily metastasizes. Tetrahydrocurcumin (THC) has been reported to have anti-tumor activity in numerous tumors. In addition, hypoxia-inducible factor-1α (HIF-1α) has been demonstrated to be associated with tumor metastasis by regulating epithelial-mesenchymal transition (EMT). However, the role of THC in osteosarcoma r...

BACKGROUND False-positive drug screen results for tetrahydrocannabinol (THC) have been observed. This study investigated the rate of unconfirmed positive screen results in infant and noninfant urine samples and evaluated possible reasons for differences. METHODS The rate of unconfirmed positive THC screen results for urine samples was determined retrospectively in 2 independent data sets (n =...

An increase in atmospheric CO2 concentration and the resulting global warming are typically associated with a weakening of the thermohaline circulation (THC) in model scenarios. For the models participating in the Coupled Model Intercomparison Project (CMIP), this weakening shows a significant (r 0.62) dependence on the initial THC strength; it is stronger for initially strong overturning. The ...

OBJECTIVE The aim of this study was to obtain rather rare information about the influence of chronic cannabis abuse on thyroid function. METHODS Thyroid function tests (TSH, total T3, free T4) of 39 chronic cannabis-dependent subjects (ICD-10) were determined at admission (for in-patient detoxification). In a subgroup, serum levels of thyroid hormones were correlated with the serum levels of ...

METHODS: Eleven cannabis smokers resided on a closed research unit for 51 days and received daily 0, 30, 60, and 120 mg of oral THC in divided doses for 5 days. There was a 5-puff smoked cannabis challenge on the fifth day. Each medication session was separated by 9 days of ad libitum cannabis smoking. OF was collected the evening before and throughout oral THC sessions and analyzed by 2-dimens...

Background Echocardiography can detect calcium deposits in heart valves and aortic root, but the relationship of echocardiographic heart calcification such as aortic valve calcification (AVC), mitral annular calcification (MAC), and aortic root calcification (ARC) with future cardiovascular disease (CVD) mortality and morbidity is not fully elucidated. Methods We analyzed data from 943 patien...

Abstract This paper presents the stability and rnbustncss analysis for fiizzy control system subject to paramctcr uncertainties, and the design of gains for thc fuzzy controller. Based on Lyapunov stability theory, stnbility nnd robustness conditions will be derived. The stability conditions involves only p+l linear matrix inequalities, where p i s the numbcr of rulcs of thc fuzzy controller. A...

Thc aim of this papcr is to propound an algorithn~ic approach of thc mathcmatical morphology compatible with a continuous acquisition of the image by a lincar camcra.1n accordance with the three fondanlcntal axis dcfincd hy an hexagonal frarnc , the basic twodirncnsional n~orphological transforn~atioos arc dccomposcd into lincar proccssings tl~at can bc exccutcd in parallcl This mcthod offers n...

Tele-HomeCare (THC) delivers health care at home using telephone technologies. A THC service was developed as an adjunct to existing hospital and community care systems. It connected healthcare providers to children and families at home, during the initial transition from hospital to home, using video-conferencing phones and remote vital signs monitors. The goal was to support the transition fr...