In this study we determined serum IL-8 levels in 18 untransfused patients with beta-thalassemia intermedia and in 14 subjects affected by HbH disease. As reported in polytransfused homozygous beta-thalassemia, untransfused beta-thalassemia and HbH disease show significantly (p < 0.005) higher serum IL-8 levels than normal controls. Our data suggests that there could be an intrinsic cause for th...

The amount and distribution of intranuclear suggested the presence of intranuclear hehemoglobin in erythroblasts of normal submoglobin precipitation in some cells. jects and patients with homozygous Similar characteristic absorption peaks of thalassemia were studied by microspecdenatured ferric hemoglobin were recorded trophotometric methods. The mean intranuover large inclusions of the cytopla...

Thalassemia is a hematological disorder caused by gene mutation that leads to defective synthesis of hemoglobin complex. One the complications thalassemia hypocalcemia which presented with paresthesia, muscle spasm, low-serum calcium, and intracranial calcification. Hypocalcemia can affect thalassemic patients via various mechanisms. Blood transfusion-related transfusion-independent iron overlo...

background: the reproductive and sexual health issues concerning persons affected by thalassemia major are complex. the study was planned to investigate the psychological attitudes and expectations in a group of thalassemic pregnant women attending hospital for regular blood transfusion. methods : this is a preliminary cross-sectional study involving 20 consecutive thalassemic patients and a co...

Background: Extramedullary hematopoiesis (EMH) in the middle ear is exceedingly rare, with fewer than five cases reported. The authors report the first Thai case of middle ear EMH. Case Report: A 32-year-old Thai thalassemic man presented with complaint of right-sided hearing loss from a middle ear mass. The CT/MRI was done and the diagnosis of EMH was confirmed by a pathological examination af...

Thalassemia is a genetic disease caused by disruption of globin chain synthesis leading to severe anemia and thus regular blood transfusion necessary. However, there have been known transfusions-related consequences, including iron overload multi-organ damage. The aims this study were evaluate liver cardiac function in youth adult transfusion-dependent Indonesian thalassemic patients assess its...

background: major thalassemia is the most common form of anemia requiring blood transfusion in iran. since ribavirin provokes anemia in the treated patients, interferon monotherapy may be an appropriate treatment in major thalassemic patients. the aim of this study was to determine the safety and efficacy of interferon monotherapy in thalassemic patients with hepatitis c virus infection. materi...

Objective. Thalassemic children are dependent on regular blood transfusions in order to sustain health and life. Thus, they are significantly exposed to transfusion transmitted diseases. This study was conducted to estimate the prevalence of hepatitis B and C in a group of multitransfused thalassemic children in Punjab. Methods. 116 children, ages seven and a half months to eighteen years, were...

β-thalassemia is the most common single gene disorder worldwide, in which hemoglobin β-chain production is decreased. Today, the life expectancy of thalassemic patients is increased because of a variety of treatment methods; however treatment related complications have also increased. The most common side effect is osteoporosis, which usually occurs in early adulthood as a consequence of increa...