Background: Hydroxyurea (HU) is a well known chemotherapeutic agent that has been used largely for various myeloproliferative diseases over the past 20 years. In β-thalassemia, the effect of HU is much less clear and remains controversial. This study was undertaken to describe the hematologic and clinical responses of thalassemia major and intermediate patients to HU treatment during 2 years. M...

BACKGROUND Patients with thalassemia major present chronic hemolysis and require regular blood transfusions which may cause iron overload cardiomyopathy and chronic heart failure. Hemochromatosis is characterized by excessive iron accumulation in tissues, and heart involvement is the main cause of death in patients with thalassemia. OBJECTIVE The aim of this study was to evaluate cardiac stru...

background heart failure is a major cause of death in thalassemia. the study aimed to determine the diagnostic value of n terminal pro b type natriuretic peptide (nt-pro bnp), to early diagnose the cardiac involvement in beta- thalassemia major patients. materials and methods  80 thalassemia patients aged 7 to 18 years old (patients group), and 80 healthy age and gender matched controls were en...

We describe a case of a young male without stroke risk factors who presented with a sudden onset of left-sided weakness, left hand numbness, and left eye blurriness. CT scan of the head without contrast and diffusion-weighted MRI of the brain with contrast revealed an ischemic stroke in the right middle cerebral artery distribution. Transesophageal echocardiography (TEE) revealed a mobile pedun...

Sudden cardiac death (SCD) is the leading cause of death during exercise in young athletes. Preparticipation physical examinations were developed to maintain the health and safety of athletes, including the prompt identification of those at risk for SCD. The use of medical history and physical examinations, electrocardiography, and echocardiography, or some combination thereof, is the source of...

Echocardiography is a non-invasive diagnostic technique which provides information regarding cardiac function and hemodynamics. It is the most frequently used cardiovascular diagnostic test after electrocardiography and chest X-ray. However, in a patient with acute chest pain, Transthoracic Echocardiography is essential both for diagnosing acute coronary syndrome, zeroing on the evaluation of v...

case presentation we present a case with a typical picture of myocarditis but normal echocardiographic findings, the diagnosis of which was confirmed by cardiac mri. discussion in particular, cardiac mri data are useful in borderline cases or in the presence of discrepancy between clinical picture and echocardiographic results. introduction the diagnosis of myocarditis based on a spectrum of fi...