Background—In b-thalassemia major, heart failure primarily affecting left ventricular systolic function is the most common complication and cause of death. Apart from iron deposition, it has been recently reported that myocarditis might be another contributing factor in the pathogenesis of acute or chronic heart failure, acting possibly through an autoimmune mechanism. In an attempt to assess t...

The consequences of transfusional iron overload on left ventricular diastolic filling have never been investigated systematically in patients with thalassemia major. In the present study, the pattern of left ventricular filling was assessed by Doppler echocardiography in 32 patients with thalassemia major (age, 17 +/- 5 years) who had not experienced symptoms of heart failure and had normal lef...

The present paper aims to review the main pathophysiological links between red blood cell disorders and cardiovascular diseases, provides a brief description of the latest studies in this area, and considers implications for clinical practice and therapy. Anemia is associated with a special risk in proatherosclerotic conditions and heart disease and became a new therapeutic target. Guidelines m...

BACKGROUND There are various clinical symptoms of thalassemia intermedia, and they lie roughly between those of major and minor forms of the disease. Patients with thalassemia intermedia occasionally require blood transfusions. This renders them susceptible to pulmonary arterial hypertension (PAH) syndrome, which is one of the most significant complications in patients with thalassemia intermed...

background: we sought to assess right ventricular (rv) systolic and diastolic functions via tissue doppler imaging (tdi) in order to discriminate right-to-left (bidirectional) from left-to-right intracardiac shunts. methods: a tissue doppler velocity study via doppler echocardiography was performed in 20 patients with left-to-right shunt (without evidence of significant pulmonary hypertension) ...

background: conventional doppler measurements, including mitral inflow and pulmonary venous flow, are used to estimate left ventricular end diastolic pressure (lvedp). however, these parameters have limitations in predicting lvedp among patients with mitral regurgitation. this study sought to establish whether the correlation between measurements derived from tissue doppler echocardiography and...

Error! Not a valid link. BACKGROUND: Cardiac disease caused by transfusional iron overload remains the principal cause of death in patients with βthalassemia major, despite improvements in iron chelation therapy during the past 25 years. For this reason, regular evaluation of cardiac function is recommended for all patients with thalassemia major and is now an integral part of their management....

the most common congenital diseases in children is congenital heart disease. factors such as environment, genetic, old maternal age during pregnancy, maternal disease and using medicine in pregnancy, prematuritiy, and specific seasons are significant in the prevalence of disease.materials and methods: a cross sectional study was conducted to investigate the status of children with congenital he...

BACKGROUND Prevention of myocardial siderosis is a key step to reduce rate of mortality in thalassemic patients. Our objective was to study association between echocardiography parameters and serum ferritin level in patients with major thalassemia. MATERIALS AND METHODS Sixty-six patients with major thalassemia were studied in Amir Kabir hospital, Arak, Iran. Serum ferritin levels were measur...