نتایج جستجو برای: tgm1
تعداد نتایج: 135 فیلتر نتایج به سال:
The development of the four stomachs yak is closely related to its health and performance, however underlying molecular mechanisms are largely unknown. Here, we systematically analyzed mRNAs in five growth time points [0 day, 20 days, 60 15 months 3 years (adult)] yaks. Overall, expression patterns DEmRNAs were unique at 0 d, similar d m adult stomachs. pattern abomasum was markedly different f...
The cross-linking enzyme, Transglutaminase 2 (TGase 2), contributes to physiological homeostasis and plays a role in cell death and survival. We previously showed that down-regulation of TGase 2 by cystamine or synthetic peptide R2 promotes apoptosis in drug-resistant cancer cells by restoring the level of I-kBa, leading to inactivation of NF-kB. To better define the action of TGase 2, its expr...
Rapid and Precise Determination of Zero-Field Splittings by Terahertz TimeDomain Electron Paramagnetic Resonance Spectroscopy Jian Lu1, I. Ozge Ozel2, Carina Belvin2, Xian Li1, Grigorii Skorupskii1, Lei Sun1, Benjamin K. Ofori-Okai1, Mircea Dincă1, Nuh Gedik2, and Keith A. Nelson1,* 1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA 2Department ...
An extracellular form of the calcium-dependent protein-cross-linking enzyme TGase (transglutaminase) was demonstrated to be involved in the apical growth of Malus domestica pollen tube. Apple pollen TGase and its substrates were co-localized within aggregates on the pollen tube surface, as determined by indirect immunofluorescence staining and the in situ cross-linking of fluorescently labelled...
The gene for keratinocyte transglutaminase (TGK) spans 14 kilobase pairs and contains 15 exons. Many features of the TGK gene are very similar, if not identical, to those of the gene encoding the catalytic subunit of human clotting factor XIII: they have the same number of exons, corresponding introns always interrupt the coding region in the same phase of the codon, and most exons are of simil...
PURPOSE Our goal was to investigate the effects of inhibition of transglutaminase 2 (TGase 2) on endotoxin-induced uveitis (EIU) METHODS: EIU was induced in female Lewis rats by single footpad injections of 200 microg of lipopolysaccharide (LPS). TGase 2 inhibitors were administered intraperitoneally 30 minutes before and at the time of LPS administration. Rats were sacrificed 24 hours after in...
Recombinant Semliki Forest virus (rSFV) vaccines encoding louping ill virus (LIV) genes prME and NS1 were examined. Cells transfected with rSFV-prME RNA showed correct processing of the precursor prME and the release into the medium of M and E proteins in particulate form, whilst rSFV-NS1-transfected cells secreted glycosylated, heat-labile NS1 dimers. Mice immunized with rSFV particles produce...
Steroidal anti-inflammatory drugs induce proteins that inhibit phospholipase A(2) (PLA(2)), including uteroglobin and lipocortin-1 (annexin I). Uteroglobin and lipocortin-1 retain several conserved sequences. Based on these sequences, several nonapeptides (antiflammins) were synthesized. These nonapeptides were shown to have anti-inflammatory effects in vitro and in vivo, possibly by inhibiting...
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