نتایج جستجو برای: tgfβ

تعداد نتایج: 3626  

2011
Brian A. Kennedy Daniel E. Deatherage Fei Gu Binhua Tang Michael W. Y. Chan Kenneth P. Nephew Tim H-M. Huang Victor X. Jin

Deregulation of the transforming growth factor-β (TGFβ) signaling pathway in epithelial ovarian cancer has been reported, but the precise mechanism underlying disrupted TGFβ signaling in the disease remains unclear. We performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) to investigate genome-wide screening of TGFβ-induced SMAD4 binding in epithelial ovarian cancer. Followi...

Journal: :Molecular cancer research : MCR 2017
Momeneh Foroutan Joseph Cursons Soroor Hediyeh-Zadeh Erik W Thompson Melissa J Davis

Most cancer deaths are due to metastasis, and epithelial-to-mesenchymal transition (EMT) plays a central role in driving cancer cell metastasis. EMT is induced by different stimuli, leading to different signaling patterns and therapeutic responses. TGFβ is one of the best-studied drivers of EMT, and many drugs are available to target this signaling pathway. A comprehensive bioinformatics approa...

2011
Ajit A. Kulkarni Thomas H. Thatcher Keith C. Olsen Sanjay B. Maggirwar Richard P. Phipps Patricia J. Sime

Transforming growth factor beta (TGFβ) induced differentiation of human lung fibroblasts to myofibroblasts is a key event in the pathogenesis of pulmonary fibrosis. Although the typical TGFβ signaling pathway involves the Smad family of transcription factors, we have previously reported that peroxisome proliferator-activated receptor-γ (PPAR-γ) ligands inhibit TGFβ-mediated differentiation of h...

2017
Katie L Bailey Ekta Agarwal Sanjib Chowdhury Jiangtao Luo Michael G Brattain Jennifer D Black Jing Wang

In this study, we have uncovered a novel crosstalk between TGFβ and IGF-1R signaling pathways. We show for the first time that expression and activation of IRS-1, an IGF-1R adaptor protein, is decreased by TGFβ/Smad3 signaling. Loss or attenuation of TGFβ activation leads to elevated expression and phosphorylation of IRS-1 in colon cancer cells, resulting in enhanced cell proliferation, decreas...

Journal: :Journal of the American Society of Nephrology : JASN 2013
Madeleine E Gentle Shaolin Shi Ilse Daehn Taoran Zhang Haiying Qi Liping Yu Vivette D D'Agati Detlef O Schlondorff Erwin P Bottinger

TGFβ signaling plays a central role in the development of acute and chronic kidney diseases. Previous in vivo studies involved systemic alteration of TGFβ signaling, however, limiting conclusions about the direct role of TGFβ in tubular cell injury. Here, we generated a double transgenic mouse that inducibly expresses a ligand-independent constitutively active TGFβ receptor type 1 (TβR1) kinase...

2012
Brad J. Zerlanko Laurent Bartholin Tiffany A. Melhuish David Wotton

Transforming growth factor β (TGFβ) signaling regulates cell cycle progression in several cell types, primarily by inducing a G1 cell cycle arrest. Tgif1 is a transcriptional corepressor that limits TGFβ responsive gene expression. Here we demonstrate that primary mouse embryo fibroblasts (MEFs) lacking Tgif1 proliferate slowly, accumulate increased levels of DNA damage, and senesce prematurely...

Journal: :Scientific reports 2016
Ling Liu Xu Liu Xudong Ren Yue Tian Zhenyu Chen Xiangjie Xu Yanhua Du Cizhong Jiang Yujiang Fang Zhongliang Liu Beibei Fan Quanbin Zhang Guohua Jin Xiao Yang Xiaoqing Zhang

The transforming growth factor beta (TGFβ) related signaling is one of the most important signaling pathways regulating early developmental events. Smad2 and Smad3 are structurally similar and it is mostly considered that they are equally important in mediating TGFβ signals. Here, we show that Smad3 is an insensitive TGFβ transducer as compared with Smad2. Smad3 preferentially localizes within ...

2016
Gab-Yong Bae Soon-Ki Hong Jeong-Rak Park Ok-Seon Kwon Keun-Tae Kim JaeHyung Koo Ensel Oh Hyuk-Jin Cha

Chronic exposure to TGFβ, a frequent occurrence for tumor cells in the tumor microenvironment, confers more aggressive phenotypes on cancer cells by promoting their invasion and migration while at the same time increasing their resistance to the growth-inhibitory effect of TGFβ. In this study, a transdifferentiated (TD) A549 cell model, established by chronically exposing A549 cells to TGFβ, sh...

2011
Yabing Mu Reshma Sundar Noopur Thakur Maria Ekman Shyam Kumar Gudey Mariya Yakymovych Annika Hermansson Helen Dimitriou Maria Teresa Bengoechea-Alonso Johan Ericsson Carl-Henrik Heldin Marene Landström

Transforming growth factor β (TGFβ) is a pluripotent cytokine promoting epithelial cell plasticity during morphogenesis and tumour progression. TGFβ binding to type II and type I serine/threonine kinase receptors (TβRII and TβRI) causes activation of different intracellular signaling pathways. TβRI is associated with the ubiquitin ligase tumor necrosis factor receptor (TNFR)-associated factor 6...

Journal: :Cell cycle 2010
Judith Müller Birgit Samans Jan van Riggelen Giovanni Fagà Raquel Peh K N Chia-Lin Wei Heiko Müller Bruno Amati Dean Felsher Martin Eilers

Deregulated expression of Myc under the control of an immunoglobulin enhancer induces lymphoma formation in mice. The development of lymphomas is limited by TGFβ-dependent senescence and high levels of Myc expression are continuously required to antagonize senescence. The biological processes underlying senescence are not fully resolved. We report here a comprehensive analysis of TGFβ-dependent...

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