Integrase strand transfer inhibitors (INSTIs) are the latest class of potent anti-HIV drugs. Currently, three INSTIs have been approved by the US Food and Drug Administration: raltegravir (RAL), elvitegravir (EVG) and dolutegravir (DTG). Resistance mutations to RAL and EVG emerge rapidly, and significant cross-resistance between these compounds has been documented. In addition, limited cross-re...

In this study, the combustion of olive byproducts was investigated using TG-FTIR technique. Different types biomass were considered: twigs, leaves, olive-mill waste from two-phase decanting method, and wastewater three-phase system. The reaction regions, ignition, burnout temperatures at different heating rates determined TG/DTG analysis thermogravimetry results. Comprehensive combustion, burno...

Phthalimide was reacted with chlorosulfonic acid to give sulfonic acid-functionalized phthalimide (SFP), which characterized by 1H NMR, 13C NMR, FT-IR, XRD (X-ray diffraction), SEM (scanning electron microscopy), EDX (energy-dispersive X-ray), mass, TG (thermogravimetry) and DTG (derivative thermal gravimetry) spectra. Afterward, its catalytic activity was examined for the condensation of aryla...

The thermal decomposition characteristics of microwave liquefied rape straw residues with respect to liquefaction condition and pyrolysis conversion were investigated using a thermogravimetric (TG) analyzer at the heating rates of 5, 20, 50 C min. The hemicellulose decomposition peak was absent at the derivative thermogravimetric analysis (DTG) curve of liquefied residues, because it had been d...

BACKGROUND Dolutegravir (DTG) is a once-daily unboosted second-generation integrase-inhibitor that along with two nucleoside reverse transcriptase inhibitors is one of several regimens recommended by the United States, United Kingdom and European Union for first-line antiretroviral treatment of people with HIV infection. Our objective was to review the evidence for the efficacy and safety of DT...

Pure barium zirconate nanopowders were successfully prepared in wet-chemistry synthesismethod, using barium stearate and tetra-n-butyl zirconate as Ba, Zr sources and stearic acid ascomplexing reagent. The gel was calcined at 800 and 900 °C in air. Results of thermal analysisare given, including both DTG and TG. Fourier transform infrared spectrometry (FTIR), X-raydiffraction (XRD), transmissio...

In this research different types of Al2O3 were used as supports to prepare catalysts for dehydrogenation of isobutane to isobutene. These supports were Al2O3 from Merck, Axen and gamma Al2O3 synthesized from Al(OH)3. Sn/Pt/Al2O3 catalysts were prepared by sequential impregnation, at first Pt and then Sn was deposited. Characterization of catalysts was performed by X-ray powder diffraction (XRD)...

Stoichiometric tetragonal Bal-xSrxTiO3 (x = 0.23) nanopowders were prepared by stearic acid gel(SAG) method using barium stearate, strontium stearate, tetrabutyl titanate as Ba, Sr, Ti sourcesand stearic acid as complexing reagent. Thermal analysis including differential thermogravimetric(DTG) and TG, Fourier transform infrared spectrometry (FTIR), X-ray diffraction (XRD) andtransmission electr...

Dolutegravir (DTG; S/GSK1349572) is a potent HIV-1 integrase inhibitor with a distinct resistance profile and a once-daily dose regimen that does not require pharmacokinetic boosting. This work investigated the in vitro drug transport and metabolism of DTG and assessed the potential for clinical drug-drug interactions. DTG is a substrate for the efflux transporters P-glycoprotein (Pgp) and huma...