BACKGROUND AND OBJECTIVES Urinary steroid profiling is used in doping controls to detect testosterone abuse. A testosterone over epitestosterone (T/E) ratio exceeding 4.0 is considered as suspicious of testosterone administration, irrespectively of individual heterogeneous factors such as the athlete's ethnicity. A deletion polymorphism in the UGT2B17 gene was demonstrated to account for a sign...

Testosterone (T) is not just another hormone: it is endocrinologic dynamite. Testosterone supplementation at low levels is passionately and controversially discussed among health care professionals and lay people alike, giving it a cultural, social and even a political dimension. The problem arises with decreasing levels. With an incidence of 6% in middle-aged men [1], late-onset hypogonadism (...

AIM To evaluate the testosterone mimetic properties of icariin. METHODS Forty-eight healthy male Sprague-Dawley rats at the age of 15 months were randomly divided into four groups with 12 rats each: the control group (C), the model group (M), the icariin group (ICA) and the testosterone group (T). The reproductive system was damaged by cyclophosphamide (intraperitoneal injection, 20 mg/kg x d...

This article provides data in support of the research article entitled "Rapid uptake, biotransformation, esterification and lack of depuration of testosterone and its metabolites by the common mussel, Mytilus spp." (T.I. Schwarz, I. Katsiadaki, B.H. Maskrey, A.P. Scott, 2017) [1]. The uptake of tritiated testosterone (T) from water by mussels is presented. The two main radioactive peaks formed ...

BACKGROUND Eurycoma longifolia (EL) has been shown recently to protect against bone calcium loss in orchidectomised rats, the model for androgen-deficient osteoporosis. The mechanism behind this is unclear but it may be related to its ability to elevate testosterone levels or it may directly affect bone remodeling. The aim of this study is to determine the mechanism involved by investigating th...

The hormone testosterone (T) has been linked to enhanced expression of secondary sexual traits and acquisition of mates (Ligon et al. 1990, Alatalo et al. 1996, Raouf et al. 1997). However, high plasma levels of testosterone also have been suggested to suppress immune function (Folstad and Karter 1992, Zuk et al. 1995, Hillgarth and Wingfield 1997; but see Ros et al. 1997, Hasselquist et al. 19...

Estrogen (E) and testosterone (T) are important in the sexually dimorphic pattern of blood pressure (BP) development. The goal was to examine the effects of endogenous E and exogenous T in the development of hypertension in female spontaneously hypertensive rats (SHR) on a high sodium diet. Female SHR (N = 27, 5-week) were divided into four groups: (1) control (n = 8), (2) ovariectomized (OVX, ...

Background. Aromatase inhibitors (AIs) can significantly improve semen parameters in infertile men. In this study, we investigated the efficacy of AIs for azoospermia a Chinese population with AZFc microdeletion. Aims. Patients microdeletion who were treated analyzed retrospectively by collecting clinical data, including their hormone profile and treatment outcome. divided into those sperm afte...

Preparation, evaluation and optimization of testosterone radioimmunoassay (RIA) system using liquid phase double antibody is considered to be the main objective. Three primary components were prepared and characterized to obtain valid and accurate system. These components were polyclonal testosterone antibody, the I-testosterone tracer and set of testosterone standards. The production of polycl...