Hormonally induced azoospermia is an effective, reversible form of male contraception; however, some men treated with weekly im testosterone enanthate (TE) injections fail to become azoospermic. As weekly injections cause widely fluctuating and supraphysiological testosterone levels, we tested the hypothesis that more stable, physiological testosterone levels would consistently produce azoosper...

CONTEXT The relationships between testosterone dose and its effects on sexual function, mood, and visuospatial cognition are poorly understood. OBJECTIVE To elucidate testosterone dose-response relationships in older men, we examined the effects of graded testosterone doses on sexual function, mood, and visuospatial cognition in healthy, older men (age, 60-75 yr). SETTING This study was per...

BACKGROUND Testosterone deficiency is linked to low-grade inflammation in humans, but this condition is not replicated in an animal study. The current study aims at determining the effects of testosterone deficiency and its replacement on the circulating inflammatory cytokine level in orchidectomized male rats. METHODS Three-month-old Sprague-Dawley male rats (n = 18) were randomized equally ...

Background: Anabolic androgenic steroids (AASs) represent a group of synthetic derivatives testosterone created to maximize anabolic effects and minimize the ones. Athletes use (AAS) enhance performance regardless health risk they may impact in some persons. Objective: To study histopathological biochemical changes that could occur on liver cardiac muscle after administration doping dose (supra...

Abstract Background Benign prostatic hyperplasia (BPH) is a common disease which causes various health problems for elderly men such as urinary retention, recurring tract infection and bladder stones. The aim of this study to evaluate the therapeutic effects Juniperus communis L . seed extract (JCS) on BPH in male Wistar rats. Methods To end, 30 rats were divided into 5 groups ( N = 6): group 1...

Increasing evidence in humans and other animals suggests that testosterone (T) plays an important role in modulating emotion. We previously reported that T treatment in rhesus monkeys undergoing chemically induced hypogonadism results in increased watching time of videos depicting fights between unfamiliar conspecifics (Lacreuse et al., 2010). In the current study, we aimed to further investiga...

Recent studies suggested that Eurycoma longifolia, a herbal plant, may have the potential to treat osteoporosis in elderly male. This study aimed to determine the effects of Eurycoma longifolia supplementation on the trabecular bone microarchitecture of orchidectomised rats (androgen-deficient osteoporosis model). Forty-eight-aged (10-12 months old) Sprague Dawley rats were divided into six gro...