The solubility behaviour of drug is one of the most challenging aspects in formulation development. Thus a greater understanding of dissolution and absorption behaviour of drug with low aqueous solubility is required to successfully formulate them into more soluble and hence bioavailable drug product. Therefore different approaches are being explored to enhance the solubility of poorly water so...

The objective of this study was to develop solid self-emulsifying pellets to deliver the poorly bioavailable Milk Thistle extract (Silybum Marianum) [1]. These pellets were prepared via extrusion/spheronization procedure, using a self-emulsifying system or SES (composed of Akoline MCM, Miglyol, Tween 80, Soy Lecithin and Propylene Glycol), microcrystalline cellulose and lactose monohydrate. To ...

Mixed Ta 2 O 5 – TiO binary system was studied by a combination of differential thermal analysis (DTA), scanning electron microscopy-energy dispersive spectrometry (SEM-EDS), X-ray diffraction (XRD) and in situ high temperature (HT-XRD) techniques. Different compositions the mixed oxide powders were fabricated ball–milling powdered compositions, pelletizing homogenized composite powders, heatin...

Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of Olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. Characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...

The aim of the present work was to develop immediate release dosage form of the solid dispersion of glimperide (GLIM) for potential enhancement in the bioavailability. The solid dispersions of GLIM were prepared with PEG6000, PVP K30 and Poloxamer 188, in 1:1, 1:3 and 1:5 %w/w ratio by using solvent wetting and solvent melt method. The in vitro dissolution parameters (%DE10min, %DE30min, %DE60m...

Co3W2Si intermetallic compound was synthesized by mechanical alloying (MA) of W, Co and Si elemental powder mixtures. The phase composition of the milled products was evaluated by X-ray diffraction (XRD) analysis. Morphological evolutions were characterized by transmission electron microscopy (TEM). The results showed that high energy ball milling performed in the present work led to the format...

Catalyst productivity and selectivity to C5+ hydrocarbons are critical design criteria in the choice of Fischer-Tropsch synthesis (FTS) catalysts and reactors. Cobalt-based catalysts appear to provide the best compromise between performance and cost for the synthesis of hydrocarbons from CO/H2 mixtures. Optimum catalysts with high cobalt concentration and site density can be prepared by control...