OBJECTIVE To evaluate the effects of pentoxifylline on hydrochloric acid-induced lung lesions in rats subjected to mechanical ventilation. METHODS Twenty male, adult Wistar-EPM-1 rats were anesthetized and randomly grouped (n=5 animals per group) as follows: control-MV (mechanical ventilation, MV group); bilateral instillation of HCl (HCl group); bilateral instillation of HCl followed by pent...

Fiduxosin is a new 1-adrenoceptor antagonist targeted for the treatment of symptomatic benign prostatic hyperplasia. The purpose of this study was to determine and compare the potencies of the 1-adrenoceptor antagonists terazosin, doxazosin, tamsulosin, and fiduxosin, based on relationships between plasma drug concentrations and blockade of phenylephrine (PE)-induced intraurethral (IUP) and mea...

the forced degradation study of lidocaine hcl was carried out according to the ich guideline q1a (r2). the degradation conditions were assessed to be hydrolysis, oxidation, photolysis and dry heat during 24 h, 48 h and 72 h and then the samples were investigated by gc-fid method and nuclear magnetic resonance (nmr) spectroscopy. according to these results, the degradation products were not obse...

1. In Expt I, a pelleted grass-meal diet was supplemented with hydrochloric acid, added to the grass pellets before feeding, at five levels from 0 to 628 mmol/kg dry matter (DM). Each diet was offered ad lib. for 21 d to five sheep in a 5 x 5 Latin-square design. 2. Voluntary food intake decreased rectilinearly with increasing HCl supplementation (P less than 0.001), to 42% of the control value...

to treat symptomatic patients, cancer has been ruled out, and there are no significant contraindications, all studies have shown that α-blocking agents have a significant effect on all prostates, whereas finasteride has a beneficial effect only in men with significantly large prostates and major obstructive symptoms. al. The efficacy of terazosin, finasteride, or both in benign prostatic hyperp...

Glaucoma is defined as the increase in the intraocular pressure (IOP) causing visual loss due to the circulation deficits of the aqueous humor. The IOP measurement can be obtained without any problem in calm animals. However, some animals do not allow IOP measurement without sedation or anesthesia. The purpose of this study is to determine the effect of xylazine HCl (as a sedative) and ketamine...

Background and Aim: Discolored teeth are among the most common reasons behind seeking esthetic dental treatments. Resin infiltration is a new technique for treatment of white spot lesions (WSLs). In this technique, 15% hydrochloric acid (HCl) is used to cause surface erosion. The aim of this study was to compare the enamel erosion caused by 15% and 18% HCl gels after different application times...

The BRAFV600E mutation was recently detected in hairy cell leukemia (HCL) by whole exome sequencing. To make use of this new marker for diagnosis and follow-up of HCL, we developed a BRAFV600Emut-specific quantitative real-time PCR assay and validated it in 117 HCL patients and 102 non-HCL/BRAFwt patients. The cut-off level to discriminate BRAFV600E-positive/-negative cases was set at 0.023% BR...

Traditional Chinese medicine (TCM) has been proposed to prevent urolithiasis. In China, Flos carthami (FC, also known as Carthamus tinctorius) (Safflower; Chinese name: Hong Hua/) has been used to treat urological diseases for centuries. We previously performed a screening and confirmed the in vivo antilithic effect of FC extract. Here, ex vivo organ bath experiment was further performed to stu...