Based on extensive laboratory studies to date, glutaraldehyde is not classified as a teratogen, an in vivo mutagen, or carcinogen. Several laboratory studies have shown that glutaraldehyde does not produce reproductive, teratogenic, embrofetal, or carcinogenic effects. Glutaraldehyde induces genotoxicity in some in vitro assays; however, the weight of evidence indicates glutaraldehyde is not an...

Using an in vitro assay system, polybrominated biphenyl (PBB) was assessed for its ability to inhibit metabolic cooperation between 6-thioguanine sensitive and resistant Chinese hamster V79 cells. Using a nonlethal range of the chemical, PBB was shown to inhibit metabolic cooperation (a form of cell-cell communication) in a manner similar to other known tumor promoters. Results suggest that PBB...

Maternal consumption of alcohol (ethanol) during pregnancy [5] can result in a continuum of embryonic developmental abnormalities that vary depending on the severity, duration, and frequency of exposure of ethanol during gestation [6]. Alcohol is a teratogen, an environmental agent that impacts the normal development of an embryo or fetus [7]. In addition to doserelated concerns, factors such a...

Maternal consumption of alcohol (ethanol) during pregnancy [5] can result in a continuum of embryonic developmental abnormalities that vary depending on the severity, duration, and frequency of exposure of ethanol during gestation [6]. Alcohol is a teratogen, an environmental agent that impacts the normal development of an embryo or fetus [7]. In addition to doserelated concerns, factors such a...

Maternal consumption of alcohol (ethanol) during pregnancy [5] can result in a continuum of embryonic developmental abnormalities that vary depending on the severity, duration, and frequency of exposure of ethanol during gestation [6]. Alcohol is a teratogen, an environmental agent that impacts the normal development of an embryo or fetus [7]. In addition to doserelated concerns, factors such a...

Maternal consumption of alcohol (ethanol) during pregnancy [5] can result in a continuum of embryonic developmental abnormalities that vary depending on the severity, duration, and frequency of exposure of ethanol during gestation [6]. Alcohol is a teratogen, an environmental agent that impacts the normal development of an embryo or fetus [7]. In addition to doserelated concerns, factors such a...

The risk of major and minor congenital malformations was compared in the offspring of diabetic (n = 2,639) and nondiabetic (n = 2,144) women who delivered at the Johns Hopkins Hospital in Baltimore, Maryland, between January 1, 1946 and December 31, 1970. In spite of ample power, there was little evidence of an increased malformation risk in offspring born prior to the onset of overt diabetes i...