BACKGROUND Although the elderly are at high risk for influenza, the immunogenicity in the elderly is lower than that in younger adults. We developed the new type of seasonal influenza vaccine with the novel intradermal (ID) injection system. In the previous exploratory phase I/II study of the ID vaccine with a dose of 15 μg HA per strain showed the superior immunogenicity profile to that of the...

OBJECTIVES To determine the reactogenicity and immunogenicity of a fourth dose of 2 three-component acellular pertussis vaccines combined with diphtheria-tetanus-acellular pertussis (DTaP) when administered at preschool age to children primed in infancy with 3 doses of the same DTaP and who had received a diphtheria-tetanus (DT) dose at the age of 12 months. SETTING Local health units of 4 It...

for evaluation the stability and potency of anthrax vaccine prepared in razi vaccine and serum research institute in iran, samples of different batches of vaccine were kept at 4-8 °c (refrigerator), 20-25 °c (room temperature) and 37 °c (incubator).the viable spores/ml of vaccines were determined using plate–counting method before and after holding at different temperatures monthly. vaccine pot...

HSV-1 disease is a significant public health burden causing orofacial, genital, cornea, and brain infection. We previously reported that trivalent HSV-2 gC2, gD2, gE2 nucleoside-modified mRNA-lipid nanoparticle (LNP) vaccine provides excellent protection against vaginal infection in mice. Here, we evaluated whether this as effective similar mRNA LNP containing gC1, gD1, gE1 the murine lip genit...

Humoral immune response using inactivated rabies vaccine was studied in 35 nelore cross-bred bovines of western region of São Paulo state. Ninety days after vaccination, 13 (92.8%) animals presented titers > or = 0.5 IU/ml, through mouse neutralization test. After 180 days, 9 (64.3%) sera showed titers > or = 0.5 IU/ml, after 270 days, only one (7.1%) showed a titer of 0.51 IU/ml, and after 360...

H2N2 Influenza A caused the Asian flu pandemic in 1957, circulated for more than 10 years and disappeared from the human population after 1968. Given that people born after 1968 are naïve to H2N2, that the virus still circulates in wild birds and that this influenza subtype has a proven pandemic track record, H2N2 is regarded as a potential pandemic threat. To prepare for an H2N2 pandemic, here...

Coffee is one of the most important agricultural products in international market and many countries are involved its production, trade or consumption. Arabica coffee self-pollinated, homozygous, normally propagated by seeds. Seeds have been considered intermediate storage behavior with varying results. It highly desirable that seeds stored safely to optimize seedling production at appropriate ...

BACKGROUND Correlations between hemagglutination-inhibition titers (hereafter "titers") and protection against infection have been identified in historical studies. However, limited information is available about the dynamics of how titer influences protection. METHODS Titers were measured in randomized, placebo-controlled vaccine trials in Hong Kong among pediatrics during September 2009-Dec...

BACKGROUND In the US, influenza vaccination is recommended annually to everyone ≥6months. Prior receipt of influenza vaccine can dampen antibody responses to subsequent vaccination. This may have implications for pregnant women and their newborns, groups at high risk for complications from influenza infection. OBJECTIVE This study examined effects of prior vaccination on maternal and cord blo...