نتایج جستجو برای: telomerase

تعداد نتایج: 8174  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2000
T Kanaya S Kyo K Hamada M Takakura Y Kitagawa H Harada M Inoue

Telomerase activation is a critical step in cellular immortality and oncogenesis. The activity of telomerase is known to be correlated with cell proliferation, but its regulation by cell cycle regulators is not well understood. In the present study, we examined the effects of p53 on telomerase activity. Wild-type p53 was introduced into SiHa cells via a recombinant adenoviral vector, Ad5CMV-p53...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1999
K Liu M M Schoonmaker B L Levine C H June R J Hodes N P Weng

Human telomerase consists of two essential components, telomerase RNA template (hTER) and telomerase reverse transcriptase (hTERT), and functions to synthesize telomere repeats that serve to protect the integrity of chromosomes and to prolong the replicative life span of cells. Telomerase activity is expressed selectively in germ-line and malignant tumor cells but not in most normal human somat...

Journal: :Oncology reports 2007
Dirk Neuhof Marc Bischof Jürgen Debus Klaus-Josef Weber

Telomerase activity in vitro represents a radiation-inducible function. To test this effect after irradiation in vivo, we measured telomerase activity in peripheral blood mononuclear cells (PBMC) of 25 patients with leukemia or lymphoma before and 1 h after whole body irradiation. Telomerase activity of the patients was compared to telomerase activity in PBMC of 15 healthy volunteers. Periphera...

Journal: :Molecular cancer therapeutics 2003
Barbara A Kosciolek Kriton Kalantidis Martin Tabler Peter T Rowley

Telomerase is an attractive molecular target toward which to direct cancer therapeutic agents because telomerase activity is present in most malignant cells but undetectable in most normal somatic cells. Short duplex RNA (short-interfering RNA or siRNA) has recently been shown to be an effective method for inhibiting the expression of a given gene in human cells. Accordingly, we evaluated the a...

2000
Taro Kanaya Satoru Kyo Katsuyuki Hamada Masahiro Takakura Yasuhide Kitagawa Hironobu Harada Masaki Inoue

Telomerase activation is a critical step in cellular immortality and oncogenesis. The activity of telomerase is known to be correlated with cell proliferation, but its regulation by cell cycle regulators is not well understood. In the present study, we examined the effects of p53 on telomerase activity. Wild-type p53 was introduced into SiHa cells via a recombinant adenoviral vector, Ad5CMV-p53...

Journal: :Cancer research 1995
E Hiyama T Yokoyama N Tatsumoto K Hiyama Y Imamura Y Murakami T Kodama M A Piatyszek J W Shay Y Matsuura

Although many genetic alterations have been reported in gastric cancer, it is not known whether all gastric tumors are capable of indefinite proliferative potential, e.g., immortality. The expression of telomerase and stabilization of telomeres are concomitant with the attainment of immortality in tumor cells; thus, the measurement of telomerase activity in clinically obtained tumor samples may...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2005
Yidong Fan Zhaoxu Liu Xiaolei Fang Zheng Ge Nan Ge Yong Jia Peng Sun Fenglan Lou Magnus Björkholm Astrid Gruber Peter Ekman Dawei Xu

Activation of telomerase, a key event during immortalization and malignant transformation, requires expression of the telomerase reverse transcriptase (hTERT). Consistently, lack of telomerase activity and hTERT expression occurs in most normal human somatic cells. However, it has been observed that both normal and cancerous renal tissues express hTERT whereas only the latter exhibits telomeras...

Journal: :Brain, behavior, and immunity 2010
Elissa S Epel Jue Lin Firdaus S Dhabhar Owen M Wolkowitz E Puterman Lori Karan Elizabeth H Blackburn

Telomerase activity plays an essential role in cell survival, by lengthening telomeres and promoting cell growth and longevity. It is now possible to quantify the low levels of telomerase activity in human leukocytes. Low basal telomerase activity has been related to chronic stress in people and to chronic glucocorticoid exposure in vitro. Here we test whether leukocyte telomerase activity chan...

Journal: :Bioorganic and Medicinal Chemistry Reports 2020

Journal: :Journal of clinical pathology 1999
S Ferlicot V Paradis D Dargère G Monges P Bedossa

BACKGROUND While telomerase is undetectable in most normal somatic tissues, telomerase activation has been detected in many immortal cell lines and various cancers. AIM To investigate telomerase expression in hepatocellular carcinoma, and to assess the expression of the RNA component of telomerase, hTR. METHODS 39 hepatocellular carcinomas were studied using a telomerase polymerase chain re...

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