We have examined elongation by RNA polymerase II initiated at a promoter and have identified two classes of elongation complexes. Following initiation at a promoter, all polymerase molecules enter an abortive mode of elongation. Abortive elongation is characterized by the rapid generation of short transcripts due to pausing of the polymerase followed by termination of transcription. Termination...

Using a new-generation open-circuit calorimeter capable of monitoring the cost of activity, and thereby both the real thermic effect of feeding (TEF) and basal metabolism in free-moving freely-feeding rats, we have reassessed the proposal that when food intake is restricted an adaptative reduction in energy expenditure participates in the achievement of energy balance. Total energy expenditure,...

Objective: To compare frequency of anastomotic leak with ligation versus preservation azygos vein in the primary repair esophageal atresia (EA) trachea-esophageal fistula (TEF) neonates. Study Design: Randomized Controlled Trial. Setting: Department Pediatric Surgery, Pakistan Institute Medical Sciences, Islamabad. Period: October 2019 to September 2020. Material & Methods: This study invol...

BACKGROUND Thermic effect of a meal (TEF) has previously been suggested to influence appetite. OBJECTIVE The aim of this study was to assess whether there is an association between appetite and TEF. Second, to examine whether protein intake is associated with TEF or appetite. DESIGN Individual participant data (IPD) meta-analysis on studies were performed at the Department of Nutrition, Exe...

BACKGROUND Esophageal atresia (EA) is the most frequent and severe congenital anomaly of the esophagus, occurring in 1:2500-1:4500 live births. Five types of EA have been described, EA with tracheoesophageal fistula (TEF) being the most frequent. AIM The aim of this paper is to evaluate epidemiological aspects, malformative associations, and prenatal diagnosis in an unusual case series of EA ...

Chronic, long-term respiratory morbidity (CRM) is common in patients with a history of repaired congenital esophageal atresia, typically associated with tracheoesophageal fistula (EA/TEF). EA/TEF patients are at high risk of having aspiration, and retrospective studies have associated CRM with both recurrent aspiration and atopy. However, studies evaluating the association between CRM in this p...

OBJECTIVE To study the oncogenic potential of mouse translation initiation factor 3 (TIF3) and elongation factor-1delta (TEF-1delta) in malignant transformed human bronchial epithelial cells induced by crystalline nickel sulfide (NiS). METHODS Abnormal expressions of human TIF3 and TEF-1delta genes in two kinds of NiS-transformed cells and NiS-tumorigenic cell lines were investigated and anal...

Eragrostis tef (Zucc.), a member of the Chloridoideae subfamily of grasses, is one of the most important food crops in Ethiopia. Lodging is the most important production problem in tef. The rht1 and sd1 dwarfing genes have been useful for improving lodging resistance in wheat and rice, respectively, in what has been known as the "Green Revolution." All homologs of rht1 and sd1 were cloned and s...

a twenty-year-old girl was referred with tracheal stenosis (ts) which was a consequence of prolonged intubation after head injury because of previous car accident. the patient was aphasic and had normal respiration. fiberoptic bronchoscopy showed complete tracheal obstruction at second tracheal ring level. distal trachea was normal through tracheostomy tube. removal of the tracheostomy tube and...

cluder (Amplatzer septal occluder [ASO]; AGA Corporation, Plymouth, Minnesota, USA), which is commonly adopted to close cardiac septal defects [1], but was used in the present case to treat an 83-year-old patient with a benign tracheoesophageal fistula (TEF). The TEF, which was caused by the accidental ingestion of dental amalgam, was previously treated unsuccessfully by the placement of a plas...